Description

1-(Bromomethyl)-4-(trifluoromethyl)benzene (CAS No. 402-49-3) is a high-purity aromatic compound with the molecular formula C₈H₆BrF₃. This organobromine reagent features a reactive benzyl bromide group adjacent to an electron-withdrawing trifluoromethyl substituent, making it a versatile building block for synthetic organic chemistry. The compound is supplied as a clear to pale yellow liquid with a characteristic aromatic odor, and is typically packaged under inert atmosphere to ensure stability. With a molecular weight of 239.04 g/mol, this reagent is particularly valuable for nucleophilic substitution reactions, transition metal-catalyzed couplings, and as a precursor for pharmaceuticals and agrochemicals. Our product undergoes rigorous QC testing including GC-MS and NMR analysis to guarantee >98% purity, making it suitable for demanding research applications in medicinal chemistry and materials science.

Properties

• CAS Number: 402-49-3
• Complexity: 136
• IUPAC Name: 1-(bromomethyl)-4-(trifluoromethyl)benzene
• InChI: InChI=1S/C8H6BrF3/c9-5-6-1-3-7(4-2-6)8(10,11)12/h1-4H,5H2
• InChI Key: IKSNDOVDVVPSMA-UHFFFAOYSA-N
• Exact Mass: 237.96050
• Molecular Formula: C8H6BrF3
• Molecular Weight: 239.03
• SMILES: C1=CC(=CC=C1CBr)C(F)(F)F
• Monoisotopic Mass: 237.96050
• Synonyms: 4-(Trifluoromethyl)benzyl bromide, 402-49-3, 1-(Bromomethyl)-4-(trifluoromethyl)benzene, Benzene, 1-(bromomethyl)-4-(trifluoromethyl)-, EINECS 206-947-8, DTXSID30193196, DTXCID40115687, 206-947-8, 4-Trifluoromethylbenzyl bromide, 4-(Bromomethyl)benzotrifluoride, p-Trifluoromethylbenzyl bromide, MFCD00000403, 4-(trifluoromethyl)benzylbromide, 4-trifluoromethyl benzyl bromide, p-(trifluoromethyl)benzyl bromide, alpha’-Bromo-alpha,alpha,alpha-trifluoro-p-xylene, 4-trifluoromethylbenzylbromide, 4-(trifluoromethyl)-benzyl bromide, alpha’-Bromo-alpha,alpha,alpha-trifluoro-p-xylene; 1-(Bromomethyl)-4-(trifluoromethyl)benzene; 1-Trifluoromethyl-4-(bromomethyl)benzene; 4-Bromomethylbenzotrifluoride; p-(Trifluoromethyl)benzyl bromide; alpha’-Bromo-alpha,alpha,alpha-trifluoro-p-xylene, T5YRU2P3EP, SCHEMBL4229, 4-trifluoromethybenzyl bromide, 4-trifluoromethyl benzylbromide, 4-trifluoromethyl-benzylbromide, 4-trifluoromethylbenzyl-bromide, 4-(trifloromethyl)benzylbromide, 4-trifluromethyl benzyl bromide, p-trifluoromethyl-benzyl bromide, 4-trifluoromethyl-benzyl bromide, 4-(trifluoromethyl)-benzylbromide, 4-(Trifluoromethyl) benzylbromide, 4-(trifluoromethyl) benzyl bromide, 4-trifluoromethylphenylmethyl bromide, A’-Bromo-A,A,A-trifluoro-p-xylene, BBL027295, bromomethyl-4-trifluoromethyl-benzene, SBB006698, STL377330, 1-bromomethyl-4-trifluoromethylbenzene, AKOS001171475, AC-9767, CS-W018337, FT34370, GS-3501, 1-bromomethyl-4-trifluoromethyl-benzene, 4-(Trifluoromethyl)benzyl bromide, 98%, [4-(trifluoromethyl)-phenyl]methyl bromide, 4-(bromomethyl)-1-(trifluoromethyl)benzene, DB-024000, NS00043748, ST51039973, T1313, 1-(Bromomethyl)-4-(trifluoromethyl)benzene #, EN300-15248, alpha-Bromo-alpha’,alpha’,alpha’-trifluoro-p-xylene, F2190-0266, .alpha.’-Bromo-.alpha.,.alpha.,.alpha.-trifluoro-p-xylene, 4-(Trifluoromethyl)benzyl bromide, 60% in dichloromethane, 4-(Bromomethyl)benzotrifluoride;a’-Bromo-a,a,a-trifluoro-p-xylene

Application

This benzyl bromide derivative is widely used as an alkylating agent in pharmaceutical intermediate synthesis, particularly for introducing the 4-(trifluoromethyl)benzyl moiety. It serves as a key precursor in the preparation of bioactive molecules including kinase inhibitors and antimicrobial agents. The compound’s reactivity makes it valuable for creating liquid crystals and advanced materials with tailored electronic properties.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.