Description

1-(Bromomethyl)-2,4-difluorobenzene (CAS No. 23915-07-3) is a high-purity aromatic organobromine compound with the molecular formula C₇H₅BrF₂. This versatile reagent features a reactive bromomethyl group adjacent to two fluorine substituents on a benzene ring, making it an essential building block for pharmaceutical, agrochemical, and materials science applications. The compound is supplied as a clear to pale yellow liquid with >98% purity (GC), stabilized for optimal shelf life. Its unique structure enables selective functionalization in cross-coupling reactions, nucleophilic substitutions, and as a precursor for heterocyclic synthesis. Proper handling under inert atmosphere is recommended due to sensitivity to moisture and light. Packaged in amber glass bottles with secure closures to ensure stability during shipping and storage.

Properties

• CAS Number: 23915-07-3
• Complexity: 108
• IUPAC Name: 1-(bromomethyl)-2,4-difluoro-benzene
• InChI: InChI=1S/C7H5BrF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
• InChI Key: IBLMYGXJKQIGSN-UHFFFAOYSA-N
• Exact Mass: 205.95427
• Molecular Formula: C7H5BrF2
• Molecular Weight: 207.01
• SMILES: C1=CC(=C(C=C1F)F)CBr
• Monoisotopic Mass: 205.95427
• Synonyms: 2,4-Difluorobenzyl bromide, 23915-07-3, 1-(Bromomethyl)-2,4-difluorobenzene, Benzene, 1-(bromomethyl)-2,4-difluoro-, EINECS 245-938-3, IBLMYGXJKQIGSN-UHFFFAOYSA-, DTXSID50178627, DTXCID10101118, 245-938-3, inchi=1/c7h5brf2/c8-4-5-1-2-6(9)3-7(5)10/h1-3h,4h2, 2,4-difluorobenzylbromide, alpha-Bromo-2,4-difluorotoluene, MFCD00011649, 1-(bromomethyl)-2,4-difluoro-benzene, 1-bromomethyl-2,4-difluoro-benzene, 2,4 difluorobenzylbromide, 2,4difluorobenzyl bromide, 2,4-diflurobenzyl bromide, 2,4 difluorobenzyl bromide, 2,4-difluoro-benzylbromide, 2.4-difluorobenzyl bromide, 2, 4-difluorobenzyl bromide, 2,4-Difluoro-benzyl bromide, A-bromo-2,4-difluorotoluene, SCHEMBL120150, 1-bromomethyl-2,4-difluorobenzene, 2,4-Difluorobenzyl bromide, 98%, .alpha.-Bromo-2,4-difluorotoluene, CS-D1155, SBB006567, 1-bromomethyl -2,4-difluoro-benzene, AKOS005063939, AC-9733, 1-(Bromomethyl)-2,4-difluorobenzene #, PS-10024, 1-(bromomethyl)-2,4-bis(fluoranyl)benzene, DB-023842, A4976, B1710, NS00051680, ST51039955, EN300-129589, A816987, F0001-0818

Application

1-(Bromomethyl)-2,4-difluorobenzene serves as a key intermediate in Suzuki-Miyaura cross-coupling reactions for biaryl synthesis. It is widely employed in pharmaceutical research for constructing fluorinated drug candidates, particularly CNS-active compounds and kinase inhibitors. The compound also finds use in liquid crystal material development and as a precursor for advanced ligands in catalytic systems.

Safety and Hazards

GHS Hazard Statements

• H226 (89.8%): Flammable liquid and vapor [Warning Flammable liquids]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H317 (91.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H334 (83.7%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P333+P317, P342+P316, P362+P364, P363, P370+P378, P403, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (89.8%)
• Skin Corr. 1B (100%)
• Skin Sens. 1 (91.8%)
• Resp. Sens. 1 (83.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.