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Atomfair 1-(Bromomethyl)-2-chloro-4-fluorobenzene 2-Chloro-4-fluorobenzyl bromide C7H5BrClF

Description 1-(Bromomethyl)-2-chloro-4-fluorobenzene (CAS No. 45767-66-6) is a high-purity halogenated aromatic compound with the molecular formula C7H5BrClF. This versatile intermediate features a reactive bromomethyl group adjacent to chloro and fluoro substituents on a benzene ring, making it ideal for nucleophilic substitution reactions, cross-coupling chemistry, and pharmaceutical synthesis. With a molecular weight of 223.47 g/mol, this compound is supplied as a clear to pale yellow liquid (or low-melting solid) and should be stored under inert conditions due to its moisture-sensitive nature. Its unique substitution pattern enables regioselective functionalization, offering researchers precise control in complex organic transformations. GC/HPLC analysis confirms purity ??95%, with…

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Description

Description

1-(Bromomethyl)-2-chloro-4-fluorobenzene (CAS No. 45767-66-6) is a high-purity halogenated aromatic compound with the molecular formula C7H5BrClF. This versatile intermediate features a reactive bromomethyl group adjacent to chloro and fluoro substituents on a benzene ring, making it ideal for nucleophilic substitution reactions, cross-coupling chemistry, and pharmaceutical synthesis. With a molecular weight of 223.47 g/mol, this compound is supplied as a clear to pale yellow liquid (or low-melting solid) and should be stored under inert conditions due to its moisture-sensitive nature. Its unique substitution pattern enables regioselective functionalization, offering researchers precise control in complex organic transformations. GC/HPLC analysis confirms purity ??95%, with detailed technical data available upon request.

  • CAS No: 45767-66-6
  • Molecular Formula: C7H5BrClF
  • Molecular Weight: 223.47
  • Exact Mass: 221.92472
  • Monoisotopic Mass: 221.92472
  • IUPAC Name: 1-(bromomethyl)-2-chloro-4-fluorobenzene
  • SMILES: C1=CC(=C(C=C1F)Cl)CBr
  • Synonyms: 1-(bromomethyl)-2-chloro-4-fluorobenzene, 642-573-5, 2-Chloro-4-fluorobenzyl bromide, 45767-66-6, MFCD00236025

Application

This compound serves as a key building block in medicinal chemistry for introducing 2-chloro-4-fluorobenzyl motifs into drug candidates. It’s particularly valuable in synthesizing kinase inhibitors and CNS-active compounds where the halogen pattern modulates bioactivity. The reactive benzylic bromide participates efficiently in Suzuki couplings, aminations, and other transition metal-catalyzed reactions.

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