Description

1-(Bromomethyl)-2-chloro-3-(trifluoromethyl)benzene (CAS No. 261763-22-8) is a high-purity halogenated aromatic compound with the molecular formula C₈H₅BrClF₃. This versatile intermediate is widely used in organic synthesis, pharmaceutical research, and agrochemical development. Its unique structure, featuring bromomethyl, chloro, and trifluoromethyl substituents on a benzene ring, makes it an excellent building block for nucleophilic substitution reactions, cross-coupling reactions, and the synthesis of complex fluorinated molecules. Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Ideal for researchers requiring reliable, high-quality reagents for advanced chemical transformations.

Properties

• CAS Number: 261763-22-8
• Complexity: 171
• IUPAC Name: 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)benzene
• InChI: InChI=1S/C8H5BrClF3/c9-4-5-2-1-3-6(7(5)10)8(11,12)13/h1-3H,4H2
• InChI Key: ZPHUUSQDKIEPDN-UHFFFAOYSA-N
• Exact Mass: 271.92152
• Molecular Formula: C8H5BrClF3
• Molecular Weight: 273.48
• SMILES: C1=CC(=C(C(=C1)C(F)(F)F)Cl)CBr
• Monoisotopic Mass: 271.92152
• Synonyms: 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)benzene, 670-761-7, 261763-22-8, 2-Chloro-3-(trifluoromethyl)benzyl bromide, Benzene, 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)-, 2-CHLORO-3-(TRIFLUOROMETHYL)BENZYLBROMIDE, MFCD01631539, SCHEMBL488470, DTXSID50381159, AKOS015850235, JS-4147, s10884, 2-chloro-3-(trifluromethyl)benzyl bromide, DB-102783, EN300-7385749, 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)-benzene, 1-(bromomethyl)-2-chloro-3-(trifluoromethyl)b enzene

This compound serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. It is particularly useful in the preparation of trifluoromethyl-substituted aromatic compounds via nucleophilic substitution or metal-catalyzed coupling reactions. Researchers also employ it in the development of bioactive molecules and materials science applications. Proper handling under inert conditions is recommended due to its reactive bromomethyl group.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H335 (16.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P260, P261, P264, P271, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)
• STOT SE 3 (16.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.