Description

1-Bromo-4-(methylsulphonyl)benzene (CAS No. 3466-32-8) is a high-purity sulfone derivative with the molecular formula C₇H₇BrO₂S. This compound, also known by its IUPAC name 1-bromo-4-methylsulfonylbenzene, is a versatile intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. Its crystalline solid form and well-defined structure make it ideal for precise reactions, including nucleophilic substitutions and cross-coupling reactions. With a purity grade suitable for research and industrial applications, this product is rigorously tested via GC, HPLC, and NMR to ensure consistency and reliability. Store in a cool, dry place away from light to maintain stability.

Properties

• CAS Number: 3466-32-8
• Complexity: 209
• IUPAC Name: 1-bromo-4-methylsulfonyl-benzene
• InChI: InChI=1S/C7H7BrO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H3
• InChI Key: FJLFSYRGFJDJMQ-UHFFFAOYSA-N
• Exact Mass: 233.93501
• Molecular Formula: C7H7BrO2S
• Molecular Weight: 235.10
• SMILES: CS(=O)(=O)C1=CC=C(C=C1)Br
• Topological: 42.5
• Monoisotopic Mass: 233.93501
• Synonyms: 4-Bromophenyl methyl sulfone, 3466-32-8, Benzene, 1-bromo-4-(methylsulfonyl)-, p-Bromophenyl methyl sulfone, Methyl 4-bromophenyl sulfone, Sulfone, p-bromophenyl methyl, 1-Bromo-4-(methylsulphonyl)benzene, NSC 174742, EINECS 222-421-0, DTXSID20188218, DTXCID50110709, Sulfone, p-bromophenyl methyl (8CI), Benzene, 1-bromo-4-(methylsulfonyl)-(9CI), 222-421-0, 1-Bromo-4-(methylsulfonyl)benzene, 1-bromo-4-methylsulfonylbenzene, 1-bromo-4-methanesulfonylbenzene, 4-bromophenyl methyl sulphone, 4-bromo phenyl methyl sulfone, MFCD00025065, A1H6Y, p-methyl benzenesulfobromide, 1-bromo-4-mesylbenzene, 4-bromophenylmethyl-sulfone, 4-bromophenylsulfonylmethane, 4-methylsulfonylbromobenzene, TimTec1_001578, 4-methylsulfonyl-bromobenzene, 4-methanesulfonyl-bromobenzene, SCHEMBL387826, SCHEMBL759489, 4-(methanesulfonyl)bromobenzene, Bromo-4-methanesulfonyl benzene, SCHEMBL18230264, 1-bromo-4-methylsulfonyl benzene, 1-Bromo-4-methanesulfonyl-benzene, 4-bromo-1-(methylsulfonyl)benzene, HMS1538H16, CS-B0933, 4-Bromophenyl methyl sulfone, 97%, NSC174742, SBB006294, 1-Bromo-4-(methylsulfonyl)benzene #, AKOS003342591, AB01453, NSC-174742, NCGC00174282-01, AS-15028, ST024136, SY026610, DB-048670, B3148, NS00029705, EN300-95338, AH-034/32832061, Z432550092, InChI=1/C7H7BrO2S/c1-11(9,10)7-4-2-6(8)3-5-7/h2-5H,1H

Application

1-Bromo-4-(methylsulphonyl)benzene is widely used as a key intermediate in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to synthesize biaryl compounds. It serves as a precursor in the development of sulfone-containing pharmaceuticals, including kinase inhibitors and anti-inflammatory agents. Additionally, this compound is employed in agrochemical research for the design of novel herbicides and fungicides.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (87.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (87.5%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.