Description

1-Bromo-4-fluorobenzene (CAS No. 460-00-4) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄BrF. This versatile intermediate is widely used in organic synthesis, pharmaceutical research, and material science applications. The compound features a benzene ring substituted with bromine and fluorine atoms in the para position, offering excellent reactivity for cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings.

Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Ideal for use as a building block in medicinal chemistry, agrochemical development, and liquid crystal synthesis. Available in quantities from grams to multi-kilogram scale with customizable packaging options.

Key specifications:

• Molecular Weight: 175.00 g/mol
• Appearance: Clear colorless to pale yellow liquid
• Boiling Point: 152-154°C
• Density: 1.593 g/mL at 25°C
• Refractive Index: n²⁰/D 1.528
• Flash Point: 47°C (closed cup)

Properties

• CAS Number: 460-00-4
• Complexity: 66.9
• IUPAC Name: 1-bromo-4-fluoro-benzene
• InChI: InChI=1S/C6H4BrF/c7-5-1-3-6(8)4-2-5/h1-4H
• InChI Key: AITNMTXHTIIIBB-UHFFFAOYSA-N
• Exact Mass: 173.94804
• Molecular Formula: C6H4BrF
• Molecular Weight: 175.00
• SMILES: C1=CC(=CC=C1F)Br
• Monoisotopic Mass: 173.94804
• Physical Description: 1-bromo-4-fluorobenzene is a colorless liquid.
• Boiling Point: 306 °F at 764 mmHg
• Melting Point: 18 °F
• Flash Point: 140 °F
• Density: 1.4946 at 68 °F – Denser than water; will sink
• Vapor Pressure: 2.84 [mmHg]
• Synonyms: 1-Bromo-4-fluorobenzene, 4-Bromofluorobenzene, 4-Fluorobromobenzene, p-Bromofluorobenzene, Benzene, 1-bromo-4-fluoro-, bromofluorobenzene, UNII-A7ZH69I3KH, EINECS 207-300-2, A7ZH69I3KH, CCRIS 9387, DTXSID4027153, NSC-9460, NSC-10268, P-BROMOPHENYL FLUORIDE, 4-BROMOPHENYL FLUORIDE, 4-FLUOROBENZENE BROMIDE, DTXCID607153, CHEBI:141551, EC 207-300-2, pFluorobromobenzene, 4fluorobromobenzene, 4Bromofluorobenzene, 1Bromo4fluorobenzene, 1Fluoro4bromobenzene, 4Bromo1fluorobenzene, 4Fluoro1bromobenzene, pFluorophenyl bromide, 4Fluorophenyl bromide, 4Fluorobenzene bromide, Benzene, 1bromo4fluoro, 207-300-2, 30135-88-7, 1072-85-11073-06-9460-00-4, aitnmtxhtiiibb-uhfffaoysa-n, inchi=1/c6h4brf/c7-5-1-3-6(8)4-2-5/h1-4, un1993, 460-00-4, p-Fluorobromobenzene, 4-Fluorophenyl bromide, 1-Fluoro-4-bromobenzene, 4-Fluoro-1-bromobenzene, p-Fluorophenyl bromide, 4-bromo-1-fluorobenzene, MFCD00000342, NSC 10268, 1-bromanyl-4-fluoranyl-benzene, 4-Fluorobromobenzene;p-Bromofluorobenzene;4-Bromofluorobenzene, CAS-460-00-4, 1-bromo-4-fluoro benzene, 1-bromo-4-fluoro-benzene, p-bromoflurobenzene, parabromofluorobezene, p-bromo-fluorobenzene, 4-bromo-fluorobenzene, 4-fluoro bromobenzene, 4-Fluoro-bromobenzene, 1-bromo4-fluorobenzene, 4-bromo-fluoro-benzene, 1-bromo-4-fluorbenzene, 4-fluoro-phenyl-bromide, 1-Bromo-4-flurobenzene, 1-bromo- 4-fluorobenzene, 4-bromo-1-fluoro benzene, SCHEMBL1622, SCHEMBL147475, SCHEMBL223425, CHEMBL1876826, 1-Bromo-4-fluorobenzene, 99%, NSC9460, BCP24440, CS-D1104, NSC10268, Tox21_201379, Tox21_303305, SBB088991, AKOS000120007, 4-Bromofluorobenzene, analytical standard, NCGC00164249-01, NCGC00164249-02, NCGC00257136-01, NCGC00258930-01, BP-21440, PS-11962, B0884, NS00002575, ST50406325, 1-Bromo-4-fluorobenzene;4-Bromofluorobenzene, EN300-20498, 4-bromofluorobenzene / 1-bromo-4-fluorobenzene, 4-Bromofluorobenzene 10 microg/mL in Methanol, D84750, 4-Bromofluorobenzene 2000 microg/mL in Methanol, Q18049954, 4-Bromofluorobenzene (BFB) 2000 microg/mL in Methanol, 4-Bromofluorobenzene (BFB) 2500 microg/mL in Methanol, F0001-1247, 4-Bromofluorobenzene (BFB) 10000 microg/mL in Methanol, Y87

Application

1-Bromo-4-fluorobenzene serves as a key precursor in palladium-catalyzed cross-coupling reactions for creating biaryl structures in pharmaceutical intermediates. It’s particularly valuable in the synthesis of liquid crystal materials for display technologies due to its stable aromatic structure and halogen substituents. The compound also finds use in agrochemical production as a building block for pesticides and herbicides with enhanced biological activity.

Safety and Hazards

GHS Hazard Statements

• H226 (98.8%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (33.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (33.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (66.5%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (78.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (89.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (64.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98.8%)
• Acute Tox. 4 (33.5%)
• Acute Tox. 4 (33.5%)
• Skin Irrit. 2 (66.5%)
• Eye Irrit. 2 (78.9%)
• Acute Tox. 4 (89.4%)
• STOT SE 3 (64.6%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.