Description

1-Bromo-4-ethoxy-2,3-difluorobenzene (CAS No. 156573-09-0) is a high-purity halogenated aromatic compound with the molecular formula C₈H₇BrF₂O. This specialized chemical features a bromine substituent at the 1-position and an ethoxy group at the 4-position of a 2,3-difluorobenzene ring, offering unique reactivity for advanced synthetic applications. Its well-defined structure makes it an invaluable intermediate for pharmaceutical development, agrochemical synthesis, and materials science research. Supplied as a clear to pale yellow liquid, our product undergoes rigorous QC testing including GC, NMR, and HPLC analysis to ensure ≥98% purity. Proper storage at 2-8°C under inert atmosphere is recommended to maintain stability. Available in research quantities from milligrams to multi-gram scales with custom packaging options.

Properties

• CAS Number: 156573-09-0
• Complexity: 145
• IUPAC Name: 1-bromo-4-ethoxy-2,3-difluoro-benzene
• InChI: InChI=1S/C8H7BrF2O/c1-2-12-6-4-3-5(9)7(10)8(6)11/h3-4H,2H2,1H3
• InChI Key: OJZVBJOHBGYINN-UHFFFAOYSA-N
• Exact Mass: 235.96483
• Molecular Formula: C8H7BrF2O
• Molecular Weight: 237.04
• SMILES: CCOC1=C(C(=C(C=C1)Br)F)F
• Topological: 9.2
• Monoisotopic Mass: 235.96483
• Synonyms: 1-Bromo-4-ethoxy-2,3-difluorobenzene, 156573-09-0, 4-Bromo-2,3-difluorophenetole, 2,3-Difluoro-4-bromophenetole, 2,3-Difluoro-4-ethoxybromobenzene, Benzene, 1-bromo-4-ethoxy-2,3-difluoro-, MFCD07368018, 1-BROMO-4-ETHOXYL-2,3-DIFULOROBENZENE, SCHEMBL1243244, DTXSID00650448, OJZVBJOHBGYINN-UHFFFAOYSA-N, 1-ethoxy-2,3-difluorobromobenzene, BCP27338, SBB098712, AKOS015834840, CS-W012863, 1-bromo-4-ethoxy-2,3-difluorobenzene-, AC-23886, AS-19650, SY051187, DB-030763, B3884

Application

This compound serves as a versatile building block in organic synthesis, particularly for constructing complex fluorinated aromatic systems. Researchers utilize it in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to introduce the brominated difluorophenoxy moiety into target molecules. The ethoxy group provides additional functionality for further derivatization, making it valuable for medicinal chemistry programs developing kinase inhibitors or PET radiotracers. Its unique substitution pattern also enables applications in liquid crystal and advanced material synthesis.

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