Description

1-Bromo-3,5-difluorobenzene (CAS No. 461-96-1) is a high-purity aromatic compound with the molecular formula C₆H₃BrF₂, widely utilized in organic synthesis and pharmaceutical research. This halogenated benzene derivative features bromine and fluorine substituents at the 1, 3, and 5 positions, offering unique reactivity for cross-coupling reactions (e.g., Suzuki, Stille) and as a building block for agrochemicals, liquid crystals, and advanced materials. Our product is rigorously tested to ensure ≥98% purity (GC), with low levels of heavy metals and residual solvents, making it ideal for sensitive applications. Available in amber glass bottles or custom packaging under inert gas to ensure stability. SDS and CoA provided upon request.

Properties

• CAS Number: 461-96-1
• Complexity: 87.1
• IUPAC Name: 1-bromo-3,5-difluoro-benzene
• InChI: InChI=1S/C6H3BrF2/c7-4-1-5(8)3-6(9)2-4/h1-3H
• InChI Key: JHLKSIOJYMGSMB-UHFFFAOYSA-N
• Exact Mass: 191.93862
• Molecular Formula: C6H3BrF2
• Molecular Weight: 192.99
• SMILES: C1=C(C=C(C=C1F)Br)F
• Monoisotopic Mass: 191.93862
• Physical Description: Liquid;
• Synonyms: 1-Bromo-3,5-difluorobenzene, 461-96-1, DTXSID90196724, EC 416-710-2, DTXCID30119215, 416-710-2, 3,5-difluorobromobenzene, 461-91-6, 1-bromo-3,5-difluoro-benzene, Benzene, 1-bromo-3,5-difluoro-, MFCD00010305, 5-bromo-1,3-difluorobenzene, 1-Bromo-3,5-difluoro benzene, 3,5-difluoro bromobenzene, 3,5-difluoro-bromobenzene, 1,3-Difluoro-5-bromobenzene; 1-Bromo-3,5-difluorobenzene; 3,5-Difluoro-1-bromobenzene; 3,5-Difluorobromobenzene; 3,5-Difluorophenyl Bromide; 5-Bromo-1,3-difluorobenzene, 3,5-Difluorobromobenzen, bromo-3,5-difluorobenzene, 3,5-difluorophenyl bromide, 1-bromo3,5-difluorobenzene, 1-bromo-3,5-diflorobenzene, 1-bromo-3,5-difluorobenzen, 1-bromo-3,5-diflurobenzene, 1,3-difluoro-5-bromobenzene, 3,5-difluoro-1-bromobenzene, 1-Bromo 3,5-difluorobenzene, SCHEMBL145942, SCHEMBL146842, SCHEMBL504770, 1-Bromo -3,5-difluorobenzene, TLU63289ZZ, BCP25851, SBB091518, 1-Bromo-3,5-difluorobenzene, 98%, 1-Bromo-3 pound not5-difluorobenzene, AKOS000121085, AC-9666, CS-W001124, AC-13836, AS-11628, DB-022054, B1764, NS00009520, ST50405331, EN300-23994, InChI=1/C6H3BrF2/c7-4-1-5(8)3-6(9)2-4/h1-3

1-Bromo-3,5-difluorobenzene serves as a versatile intermediate in pharmaceutical synthesis, enabling the introduction of difluorophenyl motifs via palladium-catalyzed couplings. It is also employed in material science for designing fluorinated polymers and liquid crystals with tailored dielectric properties. Researchers value its role in constructing bioactive molecules and ligands for catalysis.

Safety and Hazards

GHS Hazard Statements

• H226: Flammable liquid and vapor [Warning Flammable liquids]
• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H315: Causes skin irritation [Warning Skin corrosion/irritation]
• H317: May cause an allergic skin reaction [Warning Sensitization, Skin]
• H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
• H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P272, P273, P280, P301+P317, P302+P352, P303+P361+P353, P319, P321, P330, P332+P317, P333+P317, P362+P364, P370+P378, P391, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (97.8%)
• Skin Irrit. 2 (97.8%)
• Skin Sens. 1 (97.8%)
• STOT RE 2 (95.6%)
• Aquatic Acute 1 (95.6%)
• Aquatic Chronic 1 (95.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.