Description

1-Bromo-3-fluorobenzene (CAS No. 1073-06-9) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄BrF. This versatile intermediate is widely utilized in organic synthesis, pharmaceutical research, and material science applications. The compound features a benzene ring substituted with bromine and fluorine at the meta position, offering unique reactivity for cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings.

Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for use as a building block in agrochemicals, liquid crystals, and active pharmaceutical ingredients (APIs). Available in quantities from grams to multi-kilogram scale with custom packaging options.

Key Specifications:
– Molecular Weight: 175.00 g/mol
– Boiling Point: 152-154°C
– Melting Point: -30°C
– Density: 1.593 g/mL at 25°C
– Refractive Index: n_D²⁰ 1.528

Properties

• CAS Number: 1073-06-9
• Complexity: 74.9
• IUPAC Name: 1-bromo-3-fluoro-benzene
• InChI: InChI=1S/C6H4BrF/c7-5-2-1-3-6(8)4-5/h1-4H
• InChI Key: QDFKKJYEIFBEFC-UHFFFAOYSA-N
• Exact Mass: 173.94804
• Molecular Formula: C6H4BrF
• Molecular Weight: 175.00
• SMILES: C1=CC(=CC(=C1)Br)F
• Monoisotopic Mass: 173.94804
• Synonyms: 1-BROMO-3-FLUOROBENZENE, Benzene, 1-bromo-3-fluoro-, EINECS 214-023-0, DTXSID9061461, DTXCID3033066, 214-023-0, inchi=1/c6h4brf/c7-5-2-1-3-6(8)4-5/h1-4, qdfkkjyeifbefc-uhfffaoysa-n, 3-Bromofluorobenzene, 1073-06-9, m-Bromofluorobenzene, m-Fluorobromobenzene, 3-Bromfluorbenzen, m-Fluorophenyl bromide, 3-fluorobromobenzene, 1-Fluoro-3-bromobenzene, Benzene, 1-fluoro-3-bromo-, NSC 10267, 3-fluoro-1-bromobenzene, MFCD00000326, NSC-10267, 3-fluoro bromobenzene, 3-bromo-1-fluorobenzene, 3-Bromfluorbenzen [Czech], 1-bromo-3-fluoro-Benzene, 3-fluoro-bromobenzene, 3-fluoro-phenylbromide, 3-fluorophenyl bromide, FP4T6BX2WD, WLN: FR CE, 3-fluoro-1-bromo benzene, 1-bromo -3-fluoro-benzene, SCHEMBL19771, SCHEMBL63128, SCHEMBL119249, SCHEMBL144267, SCHEMBL148351, SCHEMBL6204215, SCHEMBL7597527, NSC10267, 1-Bromo-3-fluorobenzene, >=99%, SBB088990, AKOS005257832, AC-9670, AS-13586, BP-21272, DB-019075, B0882, CS-0015728, NS00041960, ST50406324, EN300-39361, A20462, F0001-3944, 1-bromo-3-fluoro-benzen;1-fluoro-3-bromo-benzen;1-Fluoro-3-bromobenzene

Application

1-Bromo-3-fluorobenzene serves as a key precursor in palladium-catalyzed cross-coupling reactions for biaryl synthesis. The compound’s meta-substitution pattern enables directed metalation strategies in complex molecule construction. Researchers employ this reagent in developing fluorinated liquid crystals for display technologies and as a scaffold for PET radiotracer development. Its balanced lipophilicity and halogen reactivity make it valuable in medicinal chemistry for structure-activity relationship studies.

Safety and Hazards

GHS Hazard Statements

• H226 (97.5%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (94.9%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (96.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (94.9%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P264, P264+P265, P270, P280, P301+P317, P302+P352, P303+P361+P353, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (97.5%)
• Acute Tox. 4 (94.9%)
• Skin Irrit. 2 (96.2%)
• Eye Irrit. 2A (94.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.