Description

Description

1-Bromo-3-fluorobenzene (CAS No. 1073-06-9) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄BrF. This versatile intermediate is widely utilized in organic synthesis, pharmaceutical research, and material science applications. The compound features a benzene ring substituted with bromine and fluorine at the meta position, offering unique reactivity for cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings.

Our product is rigorously tested to ensure >98% purity (GC) and is supplied in sealed, light-resistant containers to maintain stability. Ideal for use as a building block in agrochemicals, liquid crystals, and active pharmaceutical ingredients (APIs). Available in quantities from grams to multi-kilogram scale with custom packaging options.

Key Specifications:
– Molecular Weight: 175.00 g/mol
– Boiling Point: 152-154??C
– Melting Point: -30??C
– Density: 1.593 g/mL at 25??C
– Refractive Index: n_D²⁰ 1.528

Application

1-Bromo-3-fluorobenzene serves as a key precursor in palladium-catalyzed cross-coupling reactions for biaryl synthesis. The compound’s meta-substitution pattern enables directed metalation strategies in complex molecule construction. Researchers employ this reagent in developing fluorinated liquid crystals for display technologies and as a scaffold for PET radiotracer development. Its balanced lipophilicity and halogen reactivity make it valuable in medicinal chemistry for structure-activity relationship studies.

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