Description

1-Bromo-3-chloro-5-(trifluoromethyl)benzene (CAS No. 928783-85-1) is a high-purity halogenated aromatic compound with the molecular formula C₇H₃BrClF₃. This specialty chemical is widely utilized in pharmaceutical, agrochemical, and materials science research due to its versatile reactivity as a building block for complex organic synthesis. The compound features a benzene ring substituted with bromo, chloro, and trifluoromethyl groups, offering unique electronic and steric properties for cross-coupling reactions, nucleophilic substitutions, and fluorinated intermediate synthesis. Our product is rigorously tested to ensure ≥98% purity (GC) and is supplied in sealed, light-resistant containers under inert atmosphere to maintain stability. Available in quantities from grams to kilograms to meet both laboratory and pilot-scale requirements.

Properties

• CAS Number: 928783-85-1
• Complexity: 159
• IUPAC Name: 1-bromo-3-chloro-5-(trifluoromethyl)benzene
• InChI: InChI=1S/C7H3BrClF3/c8-5-1-4(7(10,11)12)2-6(9)3-5/h1-3H
• InChI Key: QRPRXRQFNNXPBA-UHFFFAOYSA-N
• Exact Mass: 257.90587
• Molecular Formula: C7H3BrClF3
• Molecular Weight: 259.45
• SMILES: C1=C(C=C(C=C1Cl)Br)C(F)(F)F
• Monoisotopic Mass: 257.90587
• Synonyms: 928783-85-1, 1-bromo-3-chloro-5-(trifluoromethyl)benzene, DTXSID90604399, DTXCID50555156, 674-747-1, 3-Bromo-5-chlorobenzotrifluoride, MFCD09260894, Benzene, 1-bromo-3-chloro-5-(trifluoromethyl)-, SCHEMBL147500, SCHEMBL698051, SCHEMBL698165, SCHEMBL1410430, BCP22732, AKOS015919700, AB50014, BCP9000126, CS-W003600, AS-18612, SY031548, 3-BROMO-5-CHLORO-TRIFLUOROMETHYLBENZENE, EN300-142155

Application

1-Bromo-3-chloro-5-(trifluoromethyl)benzene serves as a key intermediate in the synthesis of trifluoromethyl-substituted pharmaceuticals and liquid crystal materials. The compound’s multiple halogen substituents make it valuable for sequential functionalization via Suzuki, Buchwald-Hartwig, or other transition metal-catalyzed coupling reactions. Researchers employ this building block to develop novel fluorinated compounds with enhanced biological activity or unique material properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.