Description

1-Bromo-2,6-difluorobenzene (CAS No. 64248-56-2) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃BrF₂. This specialty chemical is widely utilized in organic synthesis, pharmaceutical research, and material science due to its unique reactivity as a versatile building block. With a bromine and two fluorine substituents on the benzene ring, it offers excellent selectivity for nucleophilic substitution and cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings.

Our product is supplied as a clear to pale-yellow liquid with ≥98% purity (GC), ensuring consistency for demanding applications. It is rigorously tested for quality control, including NMR, GC-MS, and elemental analysis. Proper storage under inert conditions (nitrogen atmosphere) is recommended to maintain stability.

Key applications include:

• Intermediate in agrochemical and pharmaceutical synthesis
• Ligand precursor for catalysis
• Fluorinated material development

Available in research (5g, 25g) and bulk quantities (1kg+). SDS and CoA provided with every order.

Properties

• CAS Number: 64248-56-2
• Complexity: 87.1
• IUPAC Name: 2-bromo-1,3-difluoro-benzene
• InChI: InChI=1S/C6H3BrF2/c7-6-4(8)2-1-3-5(6)9/h1-3H
• InChI Key: HRZTZLCMURHWFY-UHFFFAOYSA-N
• Exact Mass: 191.93862
• Molecular Formula: C6H3BrF2
• Molecular Weight: 192.99
• SMILES: C1=CC(=C(C(=C1)F)Br)F
• Monoisotopic Mass: 191.93862
• Synonyms: 1-Bromo-2,6-difluorobenzene, 2-Bromo-1,3-difluorobenzene, 64248-56-2, EINECS 264-750-2, DTXSID40214462, DTXCID40136953, 264-750-2, 2,6-Difluorobromobenzene, Benzene, 2-bromo-1,3-difluoro-, 2-bromo-1,3-difluoro-benzene, MFCD00009894, m-difluorobromobenzene, KF3GX38KMW, 2,6-difluoro-bromobenzene, 1-bromo-2,6-diflurobenzene, 1,3-difluoro-2-bromobenzene, SCHEMBL191595, SCHEMBL610147, SCHEMBL3609017, SBB091517, 1-Bromo-2,6-difluorobenzene, 98%, AKOS005254380, AC-2308, CS-W007374, PS-10242, DB-009179, D1943, NS00053399, ST50405158, EN300-114163, O10671, 1-Bromo-2,6-difluorobenzene;2,6-Difluorobromobenzene, InChI=1/C6H3BrF2/c7-6-4(8)2-1-3-5(6)9/h1-3

1-Bromo-2,6-difluorobenzene serves as a key intermediate in synthesizing fluorinated pharmaceuticals and liquid crystals. The compound’s electron-deficient aromatic ring facilitates palladium-catalyzed cross-coupling reactions to create biaryl structures. Researchers employ it to develop PET radiotracers due to the fluorine-18 substitution potential. Its steric and electronic properties make it valuable for constructing ligands in asymmetric catalysis.

Safety and Hazards

GHS Hazard Statements

• H226 (98%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (98%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (98%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (98%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.