Description

1-Bromo-2,4,5-trifluorobenzene (CAS No. 327-52-6) is a high-purity halogenated aromatic compound with the molecular formula C₆H₂BrF₃. This specialized chemical is widely utilized in pharmaceutical and agrochemical research as a key intermediate for the synthesis of complex fluorinated molecules. Its unique trifluorinated structure enhances reactivity in cross-coupling reactions, making it invaluable for Suzuki, Stille, and other palladium-catalyzed transformations. Available in >98% purity (GC), our product is rigorously tested for consistency and stability, ensuring optimal performance in sensitive applications. Packaged under inert gas to prevent degradation, it is supplied in amber glass vials or custom bulk quantities to meet your research needs.

Properties

• CAS Number: 327-52-6
• Complexity: 120
• IUPAC Name: 1-bromo-2,4,5-trifluoro-benzene
• InChI: InChI=1S/C6H2BrF3/c7-3-1-5(9)6(10)2-4(3)8/h1-2H
• InChI Key: DVTULTINXNWGJY-UHFFFAOYSA-N
• Exact Mass: 209.92920
• Molecular Formula: C6H2BrF3
• Molecular Weight: 210.98
• SMILES: C1=C(C(=CC(=C1F)Br)F)F
• Monoisotopic Mass: 209.92920
• Synonyms: 1-Bromo-2,4,5-trifluorobenzene, 327-52-6, 2,4,5-trifluorobromobenzene, Benzene, 1-bromo-2,4,5-trifluoro-, 5-bromo-1,2,4-trifluorobenzene, 2-Bromo-1,4,5-trifluorobenzene, MFCD00000306, 1-Bromo-2,4,5-trifluoro-benzene, 5848WZ4MBL, EINECS 206-318-8, UNII-5848WZ4MBL, SCHEMBL270218, SCHEMBL345490, 2,4,5-Trifluoro bromo benzene, 1-bromo-2,4,5-triluorobenzene, DTXSID30186366, CHEBI:189196, 1-bromo-2,4,5-trifluoro benzene, CK2385, SBB094430, AKOS005063905, AC-9678, CS-W015084, FB46132, GS-3478, 1-Bromo-2,4,5-trifluorobenzene, 99%, B1167, NS00041535, EN300-105435, InChI=1/C6H2BrF3/c7-3-1-5(9)6(10)2-4(3)8/h1-2

Application

1-Bromo-2,4,5-trifluorobenzene serves as a versatile building block in medicinal chemistry for introducing fluorinated phenyl groups into drug candidates. It is particularly useful in the development of PET radiotracers due to its favorable leaving group properties. The compound also finds application in material science for creating liquid crystals and fluorinated polymers with enhanced thermal stability.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.8%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.