Description

1-Bromo-2,4-difluorobenzene (CAS No. 348-57-2) is a high-purity halogenated aromatic compound with the molecular formula C₆H₃BrF₂. This organofluorine building block features a bromine substituent at the 1-position and fluorine atoms at the 2- and 4-positions on the benzene ring, offering unique reactivity for nucleophilic aromatic substitution (S_NAr) and metal-catalyzed cross-coupling reactions. Supplied as a clear, colorless to pale yellow liquid (density: 1.694 g/mL at 25°C), it is particularly valuable in pharmaceutical intermediates, agrochemical synthesis, and advanced material development. The compound’s electron-deficient aromatic system makes it an excellent substrate for palladium-catalyzed Buchwald-Hartwig aminations and Suzuki-Miyaura couplings. Packaged under inert gas in amber glass bottles to ensure stability, our product undergoes rigorous QC testing (GC purity ≥98%) to meet the exacting standards of medicinal chemistry and materials science research.

Properties

• CAS Number: 348-57-2
• Complexity: 97.1
• IUPAC Name: 1-bromo-2,4-difluoro-benzene
• InChI: InChI=1S/C6H3BrF2/c7-5-2-1-4(8)3-6(5)9/h1-3H
• InChI Key: MGHBDQZXPCTTIH-UHFFFAOYSA-N
• Exact Mass: 191.93862
• Molecular Formula: C6H3BrF2
• Molecular Weight: 192.99
• SMILES: C1=CC(=C(C=C1F)F)Br
• Monoisotopic Mass: 191.93862
• Physical Description: Colorless liquid;
• Synonyms: 1-Bromo-2,4-difluorobenzene, 348-57-2, Benzene, 1-bromo-2,4-difluoro-, EINECS 206-479-4, DTXSID40188336, EC 206-479-4, DTXCID70110827, 206-479-4, 2,4-Difluorobromobenzene, 1-Bromo-2,4-difluoro-benzene, MFCD00000330, BROMO-2,4-DIFLUOROBENZENE, 2,4-Difluoro-1-bromobenzene, 2,4-Difluoro-1-bromobenzene; 2,4-Difluorobromobenzene; 2,4-Difluorophenyl Bromide; 3-Bromo-2,6-difluorobenzene; 4-Bromo-1,3-difluorobenzene, 2,4-difluoro-bromobenzene, 2,4-Difluoro bromo benzene, 1-bromo-2,4-diflurobenzene, SCHEMBL14413, 3-bromo-2,6-difluorobenzene, SCHEMBL272714, SCHEMBL1764791, SCHEMBL3144691, SBB091522, 1-Bromo-2,4-difluorobenzene, 98%, AKOS000179355, CS-W010697, FD16010, AC-10627, PS-10243, DB-025337, A6515, D1909, NS00005837, ST50405337, EN300-65437, InChI=1/C6H3BrF2/c7-5-2-1-4(8)3-6(5)9/h1-3

Application

1-Bromo-2,4-difluorobenzene serves as a versatile precursor in the synthesis of fluorinated liquid crystals for display technologies, where its differential halogen reactivity enables selective functionalization. In pharmaceutical research, it is employed to construct difluorophenyl motifs found in protease inhibitors and kinase-targeting agents. The compound’s orthogonal reactivity allows sequential modification of the bromine and fluorine positions, making it valuable for constructing complex polyfunctional aromatics in agrochemical development.

Safety and Hazards

GHS Hazard Statements

• H226 (95.6%): Flammable liquid and vapor [Warning Flammable liquids]
• H315 (94.7%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (94.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (93.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (95.6%)
• Skin Irrit. 2 (94.7%)
• Eye Irrit. 2 (94.7%)
• STOT SE 3 (93.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.