Description

1-Bromo-2-fluorobenzene (CAS No. 1072-85-1) is a high-purity halogenated aromatic compound with the molecular formula C₆H₄BrF. This colorless to pale yellow liquid is widely utilized in organic synthesis, pharmaceutical research, and material science due to its versatile reactivity as a building block for cross-coupling reactions (e.g., Suzuki, Stille, or Negishi couplings). Its ortho-substituted structure enhances steric and electronic effects, making it valuable for designing complex molecules. Packaged under inert gas to ensure stability, our 99% pure grade meets stringent quality standards (HPLC/GC) and is supplied with comprehensive analytical documentation (MSDS, COA). Suitable for use under controlled conditions (UN1993).

Properties

• CAS Number: 1072-85-1
• Complexity: 74.9
• IUPAC Name: 1-bromo-2-fluoro-benzene
• InChI: InChI=1S/C6H4BrF/c7-5-3-1-2-4-6(5)8/h1-4H
• InChI Key: IPWBFGUBXWMIPR-UHFFFAOYSA-N
• Exact Mass: 173.94804
• Molecular Formula: C6H4BrF
• Molecular Weight: 175.00
• SMILES: C1=CC=C(C(=C1)F)Br
• Monoisotopic Mass: 173.94804
• Physical Description: Colorless liquid; Aromatic odor;
• Synonyms: 1-Bromo-2-fluorobenzene, BENZENE, 1-BROMO-2-FLUORO-, 1,2-Fluorobromobenzene, EINECS 214-018-3, 2-Fluorophenyl bromide, DTXSID5061459, 2Bromfluorbenzen, oBromofluorobenzene, oFluorobromobenzene, 2Bromofluorobenzene, 2Fluorobromobenzene, 1Fluoro2bromobenzene, Benzene, 1bromo2fluoro, Benzene, 1fluoro2bromo, DTXCID3033062, 214-018-3, inchi=1/c6h4brf/c7-5-3-1-2-4-6(5)8/h1-4, ipwbfgubxwmipr-uhfffaoysa-n, un1993, 1072-85-1, 2-Bromofluorobenzene, 2-Fluorobromobenzene, o-Bromofluorobenzene, o-Fluorobromobenzene, 2-Bromfluorbenzen, 1-Fluoro-2-bromobenzene, Benzene, 1-fluoro-2-bromo-, 1-bromo-2-fluoro-benzene, NSC 59696, 2-bromo-1-fluorobenzene, MFCD00000282, NSC-59696, Benzene, bromofluoro-, 2-Bromfluorbenzen [Czech], Bromo-Fluorobenzene, 1-bromofluorobenzene, o-fluoro-bromobenzene, 1-bromo-fluorobenzene, 2-bromofluoro benzene, ortho-fluorobromobenzene, 2-Fluoro-1-bromobenzene, MTK5K5PX8N, WLN: FR BE, 1-bromo-2-fluoro benzene, SCHEMBL126173, SCHEMBL153356, SCHEMBL167821, SCHEMBL192787, SCHEMBL221930, SCHEMBL9406163, 1-Bromo-2-fluorobenzene, 99%, CS-B1543, NSC59696, SBB088989, AKOS005265496, AC-9669, PS-11963, DB-030834, B0883, NS00041959, ST50406323, EN300-52718, A20460, D77298, 1,2-Fluorobromobenzene;1-bromo-2-fluoro-benzen, Z756953644

1-Bromo-2-fluorobenzene serves as a key intermediate in synthesizing agrochemicals, liquid crystals, and active pharmaceutical ingredients (APIs). It is particularly useful in palladium-catalyzed reactions to introduce fluorophenyl motifs into target compounds. Researchers also employ it in electron-deficient aromatic systems for optoelectronic materials. Handle with appropriate PPE due to potential halogen reactivity.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (13.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (86.3%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (98%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (86.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (13.7%)
• Skin Irrit. 2 (86.3%)
• Eye Irrit. 2 (98%)
• STOT SE 3 (86.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.