Description

1-Bromo-2-chloro-4-ethoxy-3-fluorobenzene (CAS No. 909122-17-4) is a high-purity halogenated benzene derivative designed for advanced synthetic applications in pharmaceutical, agrochemical, and materials science research. With the molecular formula C₈H₇BrClFO, this compound features a unique substitution pattern of bromo, chloro, fluoro, and ethoxy functional groups, making it a versatile building block for cross-coupling reactions, nucleophilic substitutions, and other organometallic transformations. Its well-defined structure (IUPAC name: 1-bromo-2-chloro-4-ethoxy-3-fluorobenzene) ensures precise reactivity in complex multi-step syntheses. Available in rigorously tested batches (≥95% purity by GC/HPLC), this reagent is supplied in amber glass vials under inert atmosphere to maintain stability. Ideal for researchers developing novel fluorinated scaffolds or heterocyclic systems.

Properties

• CAS Number: 909122-17-4
• Complexity: 147
• IUPAC Name: 1-bromo-2-chloro-4-ethoxy-3-fluoro-benzene
• InChI: InChI=1S/C8H7BrClFO/c1-2-12-6-4-3-5(9)7(10)8(6)11/h3-4H,2H2,1H3
• InChI Key: UDCBZSCKSHVCID-UHFFFAOYSA-N
• Exact Mass: 251.93528
• Molecular Formula: C8H7BrClFO
• Molecular Weight: 253.49
• SMILES: CCOC1=C(C(=C(C=C1)Br)Cl)F
• Topological: 9.2
• Monoisotopic Mass: 251.93528
• Synonyms: 1-BROMO-2-CHLORO-4-ETHOXY-3-FLUOROBENZENE, 909122-17-4, MFCD19440929, SCHEMBL2883001, DTXSID00696902, UDCBZSCKSHVCID-UHFFFAOYSA-N, AKOS016000534, DS-1316, DA-18186, CS-0151520

Application

This compound serves as a key intermediate in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and specialty chemicals. Its orthogonal reactivity enables sequential functionalization for drug discovery, particularly in kinase inhibitor development. The ethoxy group enhances solubility for homogeneous catalysis, while the halogenated aryl core facilitates Suzuki-Miyaura or Buchwald-Hartwig couplings. Applications extend to liquid crystal materials and agrochemical precursors requiring controlled steric and electronic properties.

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