Description

1-(Benzyloxy)-2,3-difluoro-4-iodobenzene (CAS No. 146204-01-5) is a high-purity halogenated aromatic compound with the molecular formula C₁₃H₉F₂IO. This specialized chemical features a benzyloxy group adjacent to difluoro and iodo substituents on a benzene ring, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. Its IUPAC name is 2,3-difluoro-1-iodo-4-phenylmethoxybenzene, and it is characterized by its crystalline solid form under standard conditions. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor in the synthesis of complex fluorinated compounds, this product is rigorously tested for quality (≥95% purity by HPLC). Packaged under inert gas to ensure stability, it is ideal for researchers requiring precise and reactive building blocks for advanced chemical synthesis.

Properties

• CAS Number: 146204-01-5
• Complexity: 233
• IUPAC Name: 1-benzyloxy-2,3-difluoro-4-iodo-benzene
• InChI: InChI=1S/C13H9F2IO/c14-12-10(16)6-7-11(13(12)15)17-8-9-4-2-1-3-5-9/h1-7H,8H2
• InChI Key: NLXPYNYXSXAWIA-UHFFFAOYSA-N
• Exact Mass: 345.96662
• Molecular Formula: C13H9F2IO
• Molecular Weight: 346.11
• SMILES: C1=CC=C(C=C1)COC2=C(C(=C(C=C2)I)F)F
• Topological: 9.2
• Monoisotopic Mass: 345.96662
• Synonyms: 1-(benzyloxy)-2,3-difluoro-4-iodobenzene, 146204-01-5, SCHEMBL9698543, NLXPYNYXSXAWIA-UHFFFAOYSA-N, MFCD32632172, 2,3-difluoro-1-iodo-4-phenylmethoxybenzene, CS-0192245, E95581

Application

1-(Benzyloxy)-2,3-difluoro-4-iodobenzene is widely utilized as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its reactive iodine and benzyloxy groups enable participation in Suzuki-Miyaura and Ullmann-type coupling reactions. Researchers employ this compound to develop novel bioactive molecules, particularly in the study of fluorine-substituted aromatic systems. It also serves as a precursor in materials science for creating liquid crystals or OLED components.

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