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Atomfair 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)-1,2,3,6-tetrahydropyridine C18H26BNO2

Description 1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine (CAS: 1048976-83-5) is a high-purity boronic ester derivative with the molecular formula C18H26BNO2. This compound is a valuable synthetic intermediate, widely used in Suzuki-Miyaura cross-coupling reactions due to its stable pinacol boronate group. The benzyl-substituted tetrahydropyridine core enhances its reactivity in transition-metal-catalyzed transformations, making it ideal for constructing complex heterocyclic scaffolds in pharmaceutical and agrochemical research. Supplied as a crystalline solid, it is rigorously tested for purity (typically ??95% by HPLC) and stored under inert conditions to ensure stability. Suitable for use in organic synthesis, medicinal chemistry, and material science applications.

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Description

Description

1-Benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine (CAS: 1048976-83-5) is a high-purity boronic ester derivative with the molecular formula C18H26BNO2. This compound is a valuable synthetic intermediate, widely used in Suzuki-Miyaura cross-coupling reactions due to its stable pinacol boronate group. The benzyl-substituted tetrahydropyridine core enhances its reactivity in transition-metal-catalyzed transformations, making it ideal for constructing complex heterocyclic scaffolds in pharmaceutical and agrochemical research. Supplied as a crystalline solid, it is rigorously tested for purity (typically ??95% by HPLC) and stored under inert conditions to ensure stability. Suitable for use in organic synthesis, medicinal chemistry, and material science applications.

  • CAS No: 1048976-83-5
  • Molecular Formula: C18H26BNO2
  • Molecular Weight: 299.2
  • Exact Mass: 299.2056592
  • Monoisotopic Mass: 299.2056592
  • IUPAC Name: 1-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CCN(CC2)CC3=CC=CC=C3
  • Synonyms: 1048976-83-5, 1-BENZYL-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1,2,3,6-TETRAHYDROPYRIDINE, 1-Benzyl-1,2,3,6-tetrahydropyridine-4-boronic acid pinacol ester, MFCD11501654, 1-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine

Application

This compound is primarily employed as a key intermediate in palladium-catalyzed cross-coupling reactions, enabling the synthesis of biaryl and heteroaryl structures. Researchers utilize it in the development of pharmaceutical candidates, particularly for CNS-targeting molecules due to its benzyl-tetrahydropyridine moiety. It also serves as a precursor for boronic acid derivatives in sensor and polymer chemistry.

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