Description

1-(5-Amino-2-fluorophenyl)ethanone (CAS No. 67500-19-0) is a high-purity fluorinated aromatic ketone with the molecular formula C₈H₈FNO. This compound is a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials. Its unique structure, featuring an amino group and a fluorine substituent on the phenyl ring, makes it a versatile building block for constructing complex molecules. The product is supplied as a crystalline solid with ≥95% purity (HPLC), ensuring consistency for research and industrial applications. Proper storage under inert conditions is recommended to maintain stability.

Properties

• CAS Number: 67500-19-0
• Complexity: 160
• IUPAC Name: 1-(5-amino-2-fluoro-phenyl)ethanone
• InChI: InChI=1S/C8H8FNO/c1-5(11)7-4-6(10)2-3-8(7)9/h2-4H,10H2,1H3
• InChI Key: WYTBQTMYNBKLHE-UHFFFAOYSA-N
• Exact Mass: 153.058992041
• Molecular Formula: C8H8FNO
• Molecular Weight: 153.15
• SMILES: CC(=O)C1=C(C=CC(=C1)N)F
• Topological: 43.1
• Monoisotopic Mass: 153.058992041
• Synonyms: 1-(5-amino-2-fluorophenyl)ethanone, 67500-19-0, 807-410-6, 5′-Amino-2′-fluoroacetophenone, 1-(5-Amino-2-fluorophenyl)ethan-1-one, Ethanone, 1-(5-amino-2-fluorophenyl)- (9CI), 1-(5-amino-2-fluoro-phenyl)ethanone, MFCD02090052, 5-AMINO-2-FLUOROACETOPHENONE, ETHANONE, 1-(5-AMINO-2-FLUOROPHENYL)-, 5′-Amino-2′-fluoroecetophenone, SCHEMBL1440765, WYTBQTMYNBKLHE-UHFFFAOYSA-N, 1-acetyl-5-amino-2-fluorobenzene, SBB086916, AKOS015995498, CS-W007111, PS-8902, SB76286, 1-(5-amino-2-fluoro-phenyl)-ethanone, EN300-198507

Application

1-(5-Amino-2-fluorophenyl)ethanone is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. Its reactive amino and carbonyl groups enable participation in condensation, cyclization, and functionalization reactions. Researchers employ this compound in the development of fluorinated heterocycles and bioactive molecules. It is also utilized in material science for creating advanced polymers with tailored properties.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.