Description

1-(4-Chloro-2-fluorophenyl)ethan-1-one (CAS No. 175711-83-8) is a high-purity organic compound with the molecular formula C₈H₆ClFO. This aromatic ketone features a chloro- and fluoro-substituted phenyl ring, making it a valuable intermediate in synthetic organic chemistry and pharmaceutical research. Its IUPAC name is 1-(4-chloro-2-fluorophenyl)ethanone, and it is characterized by excellent stability under standard laboratory conditions. Available in >98% purity (HPLC), this compound is supplied in sealed containers to ensure integrity and longevity. Ideal for researchers developing novel drug candidates, agrochemicals, or specialty materials requiring halogenated aromatic ketones.

Properties

• CAS Number: 175711-83-8
• Complexity: 160
• IUPAC Name: 1-(4-chloro-2-fluoro-phenyl)ethanone
• InChI: InChI=1S/C8H6ClFO/c1-5(11)7-3-2-6(9)4-8(7)10/h2-4H,1H3
• InChI Key: OIGMDNONQJGUCF-UHFFFAOYSA-N
• Exact Mass: 172.0091207
• Molecular Formula: C8H6ClFO
• Molecular Weight: 172.58
• SMILES: CC(=O)C1=C(C=C(C=C1)Cl)F
• Topological: 17.1
• Monoisotopic Mass: 172.0091207
• Synonyms: 175711-83-8, 1-(4-Chloro-2-fluorophenyl)ethanone, 1-(4-Chloro-2-fluorophenyl)ethan-1-one, DTXSID90567213, DTXCID60517987, 605-759-7, 4′-Chloro-2′-fluoroacetophenone, 4-chloro-2-fluoroacetophenone, Ethanone, 1-(4-chloro-2-fluorophenyl)-, MFCD04116328, 1-(4-chloro-2-fluoro-phenyl)-ethanone, 4 inverted exclamation mark -Chloro-2 inverted exclamation mark -fluoroacetophenone, 4/’/’-CHLORO-2/’/’-FLUOROACETOPHENONE, 1-acetyl-4-chloro-2-fluorobenzene, SCHEMBL325429, SCHEMBL25176939, 4-fluoroacetophenone, OIGMDNONQJGUCF-UHFFFAOYSA-N, CL8666, SBB064338, AKOS005063601, AC-1568, FC70095, PS-8659, SY011386, CS-0094504, EN300-123641

Application

1-(4-Chloro-2-fluorophenyl)ethan-1-one serves as a key building block in the synthesis of pharmaceuticals, particularly for anti-inflammatory and CNS-active compounds. Its halogenated structure enables selective functionalization in cross-coupling reactions. Researchers also utilize it in material science for developing liquid crystals or photoactive polymers. The compound’s reactivity makes it suitable for Grignard reactions and nucleophilic substitutions.

Safety and Hazards

GHS Hazard Statements

• H302 (97.5%): Harmful if swallowed [Warning Acute toxicity, oral]

Precautionary Statements

• P264, P270, P301+P317, P330, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.5%)

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