Description

1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride (CAS: 326476-49-7) is a high-purity chemical compound with the molecular formula C₇H₇Cl₂F₃N₂, widely utilized in pharmaceutical and agrochemical research. This hydrochloride salt derivative features a pyridine core substituted with chloro and trifluoromethyl groups, offering unique reactivity for synthetic applications. It is an essential intermediate in the development of bioactive molecules, including potential herbicides, insecticides, and pharmaceutical agents targeting neurological and metabolic disorders. The product is supplied as a white to off-white crystalline powder with >98% purity (HPLC), ensuring consistency for laboratory and industrial use. Store in a cool, dry place under inert conditions to maintain stability.

Properties

• CAS Number: 326476-49-7
• Complexity: 174
• IUPAC Name: [3-chloro-5-(trifluoromethyl)-2-pyridyl]methanamine;hydrochloride
• InChI: InChI=1S/C7H6ClF3N2.ClH/c8-5-1-4(7(9,10)11)3-13-6(5)2-12;/h1,3H,2,12H2;1H
• InChI Key: DIEGHTBYTFRSDU-UHFFFAOYSA-N
• Exact Mass: 245.9938381
• Molecular Formula: C7H7Cl2F3N2
• Molecular Weight: 247.04
• SMILES: C1=C(C=NC(=C1Cl)CN)C(F)(F)F.Cl
• Topological: 38.9
• Monoisotopic Mass: 245.9938381
• Synonyms: 326476-49-7, 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methanamine hydrochloride, 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine hydrochloride, 640-341-8, (3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methanamine hydrochloride, 2-(Aminomethyl)-3-chloro-5-(trifluoromethyl)pyridine hydrochloride, 2-aminomethyl-3-chloro-5-(trifluoromethyl)pyridine hydrochloride, 2-(AMINOMETHYL)-3-CHLORO-5-(TRIFLUOROMETHYL)-PYRIDINE HYDROCHLORIDE, [3-chloro-5-(trifluoromethyl)pyridin-2-yl]methanamine Hydrochloride, MFCD00210134, [3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDYL]METHYLAMINE HYDROCHLORIDE, [3-chloro-5-(trifluoromethyl)pyridin-2-yl]methanamine;hydrochloride, 209919-84-6, [3-Chloro-5-(trifluoromethyl)-2-pyridyl]methylamine HCl, SCHEMBL637924, SCHEMBL6157878, DTXSID50938642, CHEBI:194644, (3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDIN-2-YL)METHANAMINE HCL, BCP15058, SBB100202, 1-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]methanamine hydrochloride (1:1), AKOS015846063, AC-29092, SY024970, DB-145817, CS-0157375, EN300-7423847, 10Z-0006, 2-(Aminomethyl)-3-chloro-5-(trifluoromethyl)pyridine HCl, (3-chloro-5-trifluoromethyl-2-pyridyl)methylamine hydrochloride, [3-chloro-5-(trifluoromethyl)-2-pyridyl]methylamine, chloride, 2-aminomethyl-3-chloro-5-trifluoromethylpyridine hydrochloride, (3-CHloro-5-(trifluoromethyl)pyridin-2-yl)methanamine xhydrochloride, (3-CHloro-5-(trifluoromethyl)pyridin-2-yl)methanaminexhydrochloride, [3-chloro-5-(triluoromethyl)pyridin-2-yl]methanamine;hydrochloride, 2-(Aminomethyl)-3-chloro-5-(trifluoromethyl) pyridine hydrochloride, 2-aminomethyl-3-chloro-5-(trifluoromethyl) pyridine hydrochloride, [3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-methanamine hydrochloride, 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]methanamine–hydrogen chloride (1/1)

This compound serves as a versatile building block in medicinal chemistry, particularly for synthesizing trifluoromethyl-substituted pyridine derivatives with enhanced bioactivity. Researchers employ it in the development of novel agrochemicals due to its herbicidal and insecticidal properties. It is also investigated for potential applications in CNS drug discovery, leveraging its structural motifs for target engagement. Suitable for small-scale organic synthesis and high-throughput screening workflows.

Safety and Hazards

GHS Hazard Statements

• H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (50%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2A (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.