Description

4-Bromo-2-fluoroaniline is a high-purity halogenated aniline derivative widely used in pharmaceutical and agrochemical research. This compound features a bromine and fluorine substitution on the aromatic ring, making it a versatile intermediate for Suzuki coupling, Buchwald-Hartwig amination, and other cross-coupling reactions. Its molecular formula, C₆H₅BrFN, ensures compatibility with a broad range of synthetic applications.

Supplied as a crystalline solid, 4-Bromo-2-fluoroaniline is rigorously tested for consistency and stability, ensuring reliable performance in demanding laboratory environments. Proper storage under inert conditions is recommended to maintain its integrity. This product is ideal for researchers developing novel organic compounds, including active pharmaceutical ingredients (APIs), ligands, and specialty chemicals.

Handling should follow standard laboratory safety protocols, including the use of personal protective equipment (PPE) and fume hoods. Available in flexible packaging options to suit small- and large-scale research needs.

Properties

• CAS Number: 367-24-8
• Complexity: 99.1
• IUPAC Name: 4-bromo-2-fluoro-aniline
• InChI: InChI=1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
• InChI Key: GZRMNMGWNKSANY-UHFFFAOYSA-N
• Exact Mass: 188.95894
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.01
• SMILES: C1=CC(=C(C=C1Br)F)N
• Topological: 26
• Monoisotopic Mass: 188.95894
• Synonyms: 4-Bromo-2-fluoroaniline, 367-24-8, Benzenamine, 4-bromo-2-fluoro-, EINECS 206-685-4, DTXSID90190141, DTXCID00112632, 206-685-4, GZRMNMGWNKSANY-UHFFFAOYSA-N, 2-fluoro-4-bromoaniline, 4-bromo-2-fluorobenzenamine, 4-bromo-2-fluorophenylamine, 4-bromo-2-fluoro-aniline, MFCD00010221, F2190-0460, 4-Bromo-2-fluoro-phenylamine, 4-bromo-2-fluoro aniline, 4-bromo-2fluoroaniline, 4-bromo-2 fluoroaniline, 4-bromo-6-fluoroaniline, 4bromo -2-fluoroaniline, EP4Q7AMQ8Y, 2-fluoro-4 -bromoaniline, 2-fluoro-4-bromo aniline, 2-fluoro-4-bromo-aniline, SCHEMBL57179, 2-fluoro-4-bromo-phenylamine, (4-bromo-2-fluorophenyl)amine, SCHEMBL1385188, SCHEMBL3988727, SCHEMBL8898727, SCHEMBL28282097, 4-Bromo-2-fluoroaniline, 98%, SMSSF-0613890, BCP21565, SBB040465, STL163903, AKOS000119545, AC-3654, CS-W007557, FB38205, PS-8395, DB-023937, NS00041726, ST50213767, EN300-19932, Z104476130

4-Bromo-2-fluoroaniline serves as a key building block in medicinal chemistry for the synthesis of bioactive molecules, including kinase inhibitors and antimicrobial agents. Its halogenated structure enables efficient palladium-catalyzed cross-coupling reactions, facilitating the construction of complex heterocycles. Researchers also employ it in material science for designing fluorescent dyes and liquid crystals. The compound’s reactivity makes it valuable in agrochemical development for crop protection agents.

Safety and Hazards

GHS Hazard Statements

• H302 (14.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (14.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (92.6%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (92.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (14.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (90.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (14.8%)
• Acute Tox. 4 (14.8%)
• Skin Irrit. 2 (92.6%)
• Eye Irrit. 2 (92.6%)
• Acute Tox. 4 (14.8%)
• STOT SE 3 (90.7%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.