Description

2-(4-Fluorophenyl)-2-hydroxy-1-phenylethanone (CAS No. 98453-86-2) is a high-purity fluorinated aromatic ketone with the molecular formula C₁₄H₁₁FO₂. This white to off-white crystalline solid (MW: 230.24 g/mol) is a valuable synthetic intermediate for pharmaceutical and material science research. The compound features a fluorinated phenyl ring and a chiral α-hydroxy ketone moiety, making it useful for asymmetric synthesis and medicinal chemistry applications. Packaged under inert gas in amber glass vials to ensure stability, our ≥98% purity grade (HPLC) is ideal for demanding applications. Technical specifications include: melting point 110-112°C, solubility in DMSO and ethanol, and storage recommendations at 2-8°C.

Key applications include use as a building block for: fluorinated drug candidates (particularly CNS-active compounds), liquid crystal materials, and photoinitiators. The product undergoes rigorous QC testing (GC/MS, NMR, elemental analysis) with batch-specific certificates of analysis available. Special handling precautions apply due to potential sensitivity to light and moisture.

Properties

• CAS Number: 98453-86-2
• Complexity: 253
• IUPAC Name: 2-(4-fluorophenyl)-2-hydroxy-1-phenyl-ethanone
• InChI: InChI=1S/C14H11FO2/c15-12-8-6-11(7-9-12)14(17)13(16)10-4-2-1-3-5-10/h1-9,14,17H
• InChI Key: HEJOOZZBGJQREW-UHFFFAOYSA-N
• Exact Mass: 230.07430775
• Molecular Formula: C14H11FO2
• Molecular Weight: 230.23
• SMILES: C1=CC=C(C=C1)C(=O)C(C2=CC=C(C=C2)F)O
• Topological: 37.3
• Monoisotopic Mass: 230.07430775
• Synonyms: 98453-86-2, Ethanone, 2-(4-fluorophenyl)-2-hydroxy-1-phenyl-, DTXSID40469374, DTXCID50420193, SCHEMBL6836825

Application

This fluorinated hydroxyketone serves as a key intermediate in the synthesis of potential antipsychotic and antidepressant drug candidates due to its structural similarity to known bioactive molecules. Researchers utilize it for developing fluorinated liquid crystals with improved dielectric anisotropy in display technologies. The compound’s α-hydroxy ketone functionality makes it valuable for studying asymmetric reduction reactions and chiral catalyst development.

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.