Description

2-Chloro-1,1-dimethoxyethane (CAS No. 97-97-2) is a highly versatile chlorinated acetal compound with the molecular formula C₄H₉ClO₂. This clear, colorless to pale yellow liquid is widely used in organic synthesis, pharmaceutical research, and specialty chemical applications. With a purity of ≥98%, our product is rigorously tested via GC analysis to ensure consistency for sensitive reactions. Its unique structure, featuring a reactive chloro group adjacent to a dimethoxy acetal, makes it invaluable for nucleophilic substitutions, Grignard reactions, and as a protected aldehyde equivalent. Packaged under inert gas in amber glass bottles to prevent degradation, this compound is ideal for researchers requiring high-purity intermediates. Synonyms include Chloroacetaldehyde dimethyl acetal and Dimethyl chloracetal.

Properties

• CAS Number: 97-97-2
• Complexity: 36.7
• IUPAC Name: 2-chloro-1,1-dimethoxy-ethane
• InChI: InChI=1S/C4H9ClO2/c1-6-4(3-5)7-2/h4H,3H2,1-2H3
• InChI Key: CRZJPEIBPQWDGJ-UHFFFAOYSA-N
• Exact Mass: 124.0291072
• Molecular Formula: C4H9ClO2
• Molecular Weight: 124.56
• SMILES: COC(CCl)OC
• Topological: 18.5
• Monoisotopic Mass: 124.0291072
• Synonyms: Chloroacetaldehyde dimethyl acetal, 97-97-2, 2-Chloro-1,1-dimethoxyethane, ETHANE, 2-CHLORO-1,1-DIMETHOXY-, Dimethyl chloracetal, Chloroacetaldehyde, dimethyl acetal, 2-Chloroacetaldehyde, dimethyl acetal, Acetaldehyde, chloro-, dimethyl acetal, 1-chloro-2,2-dimethoxyethane, 1KPA4H9T18, 2-Chloroacetaldehyde dimethyl acetal, EINECS 202-624-0, NSC 60388, NSC-60388, 1,1-dimethoxy-2-chloroethane, DTXSID1059157, EC 202-624-0, 2,2-DIMETHOXYETHYL CHLORIDE, DTXCID0049028, Acetaldehyde, chloro-, dimethyl acetal (8CI), 202-624-0, Dimethylchloroacetal, Dimethyl chloroacetal, 2-Chloro-1,1-dimethoxy-ethane, chloroacetaldehyde dimethylacetal, MFCD00000948, 2-?chloro-?1,?1-?dimethoxy-Ethane, Methyl Chloroacetal, UNII-1KPA4H9T18, Chloroacetaldehydedimethylacetal, Chlorodimethyl acetal, ghl.PD_Mitscher_leg0.695, SCHEMBL252600, chloracetaldehyde dimethylacetal, chloroacetaldehyde-dimethylacetal, SCHEMBL4599821, CRZJPEIBPQWDGJ-UHFFFAOYSA-, 2-chloranyl-1,1-dimethoxy-ethane, chloro acetaldehyde dimethyl acetal, BCP21838, NSC60388, BBL011494, STL146606, AKOS000121592, Chloroacetaldehyde dimethyl acetal, 98%, DA-19351, DB-351152, NS00003096, EN300-21149, 2-Chloro-1,1-dimethoxyethane;Dimethylchloroacetal, A845778, Q27252548, F0001-2309, InChI=1/C4H9ClO2/c1-6-4(3-5)7-2/h4H,3H2,1-2H3, Chloroacetaldehyde dimethyl acetal, produced by Wacker Chemie AG, Burghausen, Germany, >=99.0% (GC)

Application

2-Chloro-1,1-dimethoxyethane serves as a key building block in pharmaceutical synthesis, particularly for prodrug development and heterocyclic compound formation. It is employed as a masked aldehyde equivalent in multi-step organic transformations, enabling controlled reactivity. The compound also finds use in polymer chemistry as a crosslinking agent and in agrochemical research for pesticide intermediates.

Safety and Hazards

GHS Hazard Statements

• H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (28.7%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H332 (35.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H412 (72.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P321, P330, P362+P364, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (100%)
• Acute Tox. 4 (28.7%)
• Acute Tox. 4 (35.1%)
• Aquatic Chronic 3 (72.3%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.