Description

4-Tert-butylcyclohexane-1-carboxylic acid (CAS: 943-28-2) is a high-purity cyclohexane derivative widely used in organic synthesis and pharmaceutical research. This compound, with the molecular formula C₁₁H₂₀O₂, features a tert-butyl group at the 4-position of the cyclohexane ring, enhancing its steric and electronic properties. Ideal for researchers, it is available in various grades, including ≥98% purity, ensuring consistency in reactions such as esterification, amidation, and chiral resolution. Its stable cyclohexane backbone makes it valuable for studying conformational dynamics and steric effects in synthetic chemistry. Packaged under inert gas to prevent degradation, this product is supplied in secure, lab-ready containers with detailed analytical certificates (COA).

Properties

• CAS Number: 943-28-2
• Complexity: 183
• IUPAC Name: 4-tert-butylcyclohexanecarboxylic acid
• InChI: InChI=1S/C11H20O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h8-9H,4-7H2,1-3H3,(H,12,13)
• InChI Key: QVQKEGYITJBHRQ-UHFFFAOYSA-N
• Exact Mass: 184.146329876
• Molecular Formula: C11H20O2
• Molecular Weight: 184.27
• SMILES: CC(C)(C)C1CCC(CC1)C(=O)O
• Topological: 37.3
• Monoisotopic Mass: 184.146329876
• Synonyms: cis-4-tert-Butylcyclohexanecarboxylic acid, 4-tert-Butylcyclohexane-1-carboxylic acid, 611-163-8, 678-174-8, 943-29-3, trans-4-tert-Butylcyclohexanecarboxylic acid, 5451-55-8, 4-tert-Butylcyclohexanecarboxylic acid, 943-28-2, trans-4-(tert-Butyl)cyclohexanecarboxylic acid, 4-(tert-butyl)cyclohexanecarboxylic acid, trans-4-tert-Butylcyclohexanoic acid, Cyclohexanecarboxylicacid, 4-(1,1-dimethylethyl)-, cis-, Cyclohexanecarboxylic acid, 4-(1,1-dimethylethyl)-, cis-, Cyclohexanecarboxylic acid, 4-(1,1-dimethylethyl)-, trans-, MFCD00466237, cis-4-tert-Butylcyclohexane carboxylic acid, Cis-4-(tert-butyl)cyclohexanecarboxylic acid, Cyclohexanecarboxylic acid, 4-tert-butyl-, cis-, Cyclohexanecarboxylic acid, 4-tert-butyl-, trans-, 4-tert-Butylcyclohexanecarboxylic acid #, Cyclohexanecarboxylic acid, 4-(1,1-dimethylethyl)-, MFCD00042622, MFCD08276286, 4-tert-butylcyclohexane carboxylic acid, ChemDiv2_003455, trans-4-(dimethylethyl)cyclohexanecarboxylic acid, SCHEMBL503482, SCHEMBL1835961, SCHEMBL3514603, SCHEMBL5697616, CHEBI:87689, (1S,4S)-4-TERT-BUTYLCYCLOHEXANE-1-CARBOXYLIC ACID, DTXSID70241408, DTXSID301259837, HMS1378N01, 4-t-butylcyclohexanecarboxylic acid, NSC52180, NSC52181, 4-tert-butylcyclohexancarboxilic acid, 4-tert-butylcyclohexylcarboxylic acid, AC7380, GEO-02474, NSC 52181, NSC-52180, NSC-52181, NSC176105, NSC176107, SBB065947, ZB1703, AKOS000120233, AKOS015837821, AKOS015837823, 4-t-butylcyclohexane-1-carboxylic acid, 4-tert-butyl-cyclohexanecarboxylic acid, 4-tert-butylcyclohexane-carboxylic acid, AB06262, FB03421, NSC-176105, NSC-176107, trans-4-t-butylcyclohexanecarboxylic acid, AS-17248, AS-64517, AS-69893, SY102581, 4-tert-Butylcyclohexanecarboxylic acid,c&t, trans-4-tert-Butycyclohexanecarboxylic acid, Cis-4-(tert-butyl)cyclohexanecarboxylicacid, DB-052595, DB-057491, 4-(Tert-butyl)cyclohexane-1-carboxylic acid, 4-tert-Butylcyclohexanecarboxylic acid, 99%, B1285, B2631, CS-0081079, CS-0453487, EU-0099985, ST50307461, trans-4-tert-butyl-cyclohexanecarboxylic acid, EN300-20265, D88778, T71484, trans-4-tert-butylcyclohexane-1-carboxylic acid, (1r,4r)-4-(tert-butyl)cyclohexanecarboxylic acid, Cyclohexanecarboxylic acid,1-dimethylethyl)-, cis-, SR-01000597228, Cyclohexanecarboxylic acid,1-dimethylethyl)-, trans-, SR-01000597228-1, TRANS-4-TERT-BUTYLCYCLOHEXANE CARBOXYLIC ACID, Q27159833, Trans-4-(1,1-dimethylethyl)cyclohexanecarboxylic acid, 4-tert-Butylcyclohexanecarboxylic acid methyl ester,c&t, Z104477532, 4-tert-Butylcyclohexanecarboxylic acid, purum, >=98.0% (T)

Application

4-Tert-butylcyclohexane-1-carboxylic acid is utilized as a key intermediate in the synthesis of sterically hindered esters and chiral ligands for asymmetric catalysis. It serves as a model substrate for studying cyclohexane ring conformation and steric influences in organic reactions. Researchers also employ it in pharmaceutical development for modifying drug lipophilicity and metabolic stability.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.