Description

Hexafluoroisopropanol (HFIP) is a highly fluorinated alcohol with the molecular formula C₃H₂F₆O and CAS number 920-66-1. This specialty solvent is characterized by its strong hydrogen-bond-donating ability, low nucleophilicity, and exceptional solubility for a wide range of organic and polymeric materials. With an IUPAC name of 1,1,1,3,3,3-hexafluoropropan-2-ol, HFIP is a clear, colorless liquid with a boiling point of 58-59°C and a density of 1.596 g/mL at 25°C. Its unique properties make it invaluable in peptide chemistry, polymer dissolution, and as a solvent for NMR spectroscopy. Offered in high-purity grades (≥99%), our HFIP is rigorously tested for moisture content and acidity to ensure optimal performance in sensitive applications.

Properties

• CAS Number: 920-66-1
• Complexity: 97.1
• IUPAC Name: 1,1,1,3,3,3-hexafluoropropan-2-ol
• InChI: InChI=1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H
• InChI Key: BYEAHWXPCBROCE-UHFFFAOYSA-N
• Exact Mass: 168.00098366
• Molecular Formula: C3H2F6O
• Molecular Weight: 168.04
• SMILES: C(C(F)(F)F)(C(F)(F)F)O
• Topological: 20.2
• Monoisotopic Mass: 168.00098366
• Physical Description: 1,1,1,3,3,3-hexafluoro-2-propanol is a clear colorless oily liquid with an aromatic odor. Combustible, may cause burns to skin, eyes and mucous membranes.
• Boiling Point: 138 °F at 760 mmHg
• Melting Point: 25 °F
• Flash Point: greater than 200 °F
• Solubility: greater than or equal to 100 mg/mL at 68 °F
• Density: 1.596 at 68 °F – Denser than water; will sink
• Vapor Pressure: 158 mmHg at 72 °F ; 556 mmHg at 124 °F; 1468 mmHg at 167 °F
• Synonyms: 1,1,1,3,3,3-Hexafluoro-2-propanol, 920-66-1, Hexafluoroisopropanol, 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL, Hexafluoro-2-propanol, Hexafluoroisopropyl alcohol, Bis(trifluoromethyl)methanol, 1,1,1,3,3,3-Hexafluoroisopropanol, 2H-Hexafluoroisopropanol, 1,1,1,3,3,3-Hexafluoroisopropyl alcohol, 2-Propanol, 1,1,1,3,3,3-hexafluoro-, 2,2,2-Trifluoro-1-(trifluoromethyl)ethanol, 1,1,1,3,3,3-Hexafluoropropanol, NSC 96336, CCRIS 6043, Ethanol, 2,2,2-trifluoro-1-(trifluoromethyl)-, EINECS 213-059-4, BRN 1841007, CHEBI:63104, AI3-29336, 1,1,1,3,3,3-Hexafluoro-2-hydroxypropane, 3D632GYQ50, NSC-96336, Hexafluoro-2-propanol, 1,1,1,3,3,3-, EC 213-059-4, SEVOFLURANE IMPURITY C [EP IMPURITY], SEVOFLURANE IMPURITY C (EP IMPURITY), Hexafluoro2propanol, 2HHexafluoroisopropanol, 1,1,1,3,3,3Hexafluoropropan2ol, 1,1,1,3,3,3Hexafluoroisopropanol, 2Propanol, 1,1,1,3,3,3hexafluoro, 2,2,2Trifluoro1(trifluoromethyl)ethanol, 1,1,1,3,3,3Hexafluoroisopropyl alcohol, Ethanol, 2,2,2trifluoro1(trifluoromethyl), 213-059-4, hexafluoropropanol, HFIP, MFCD00011651, 2h-hexafluoro-2-propanol, 2H-Perfluoro-2-propanol, 1,1,1,3,3,3-hexafluoro-propan-2-ol, 1,1,1,3,3,3-HEXAFLUORO-ISOPROPANOL, 1,1,1,3,3,3-hexafluoroisopropane, hexafluoro isopropanol, 1 1 1 3 3 3-hexafluoroisopropanol, 1,1,1,3,3,3-hexafluoropropanol-2, 1,1,1,3,3,3-hexafluoro propan-2-ol, 2H-Hexafluoropropan-2-ol, UNII-3D632GYQ50, hexafluorisopropanol, hexafluoroisopropano, CFH, WLN: FXFFYQXFFF, SCHEMBL199, CF3CH(OH)CF3, Hexafluoroisopropanol, 99%, (CF3)2CHOH, NCIOpen2_001854, SCHEMBL129186, SCHEMBL144661, SCHEMBL2262667, CHEMBL1231750, DTXSID1022134, ADINBSIZWLZKPO-UHFFFAOYSA-N, QMLAKMYTRJQRMH-UHFFFAOYSA-N, 2-Propanol,hexafluoro-(8ci,9ci), 1,1,3,3,3-Hexafluoroisopropanol, BCP05614, NSC96336, MSK164763, SBB058744, 1,1,3,3,3-Hexafluoro-2-propanol, AKOS003791253, 1,1,1,3,3,3-hexafluoro isopropanol, 2-Propanol,1,1,3,3,3-hexafluoro-, FH33591, 1,1,3,3,3-Hexafluoroisopropyl alcohol, 2,2-Trifluoro-1-(trifluoromethyl)ethanol, AS-19154, BP-21416, CS-0017220, Ethanol,2,2-trifluoro-1-(trifluoromethyl)-, H0424, H1793, NS00008561, ST51037879, EN300-20423, D77965, 1,1,1,3,3,3-Hexafluoro-2-propanol, >=99%, SR-01000944926, 1,1,1,3,3,3-Hexafluoropropan-2-ol [for HPLC], Q1123466, SR-01000944926-1, 1,1,1,3,3,3-Hexafluoro-2-propanol, >=99.5%, 1,1,1,3,3,3-Hexafluoroisoproppyl alcohol [for HPLC], F9994-0607, Z104478118, 1,1,1,3,3,3-Hexafluoro-2-propanol, 99% (Peptide Grade), 1,1,1,3,3,3-Hexafluoro-2-propanol high purity grade 99.95+%, 1,1,1,3,3,3-Hexafluoro-2-propanol, puriss., >=99.0% (GC), InChI=1/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10, 1,1,1,3,3,3-Hexafluoro-2-propanol glass distilled, derivatization grade, 1,1,1,3,3,3-Hexafluoro-2-propanol, for GC derivatization, >=99.8%

Application

Hexafluoroisopropanol serves as a powerful solvent for polypeptides and synthetic polymers, particularly in circular dichroism (CD) spectroscopy studies. It is widely employed as a co-solvent in peptide synthesis to improve solubility and reduce aggregation. HFIP also finds use as a mobile phase modifier in HPLC for separating complex mixtures. Its ability to dissolve polyamides and polyesters makes it valuable in polymer processing and analysis.

Safety and Hazards

GHS Hazard Statements

• H302 (90.5%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (36%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H318 (38%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H332 (91%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (55.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H361 (10%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
• H373 (12%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]

Precautionary Statements

• P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P362+P364, P363, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (90.5%)
• Acute Tox. 4 (36%)
• Skin Corr. 1A (100%)
• Eye Dam. 1 (38%)
• Acute Tox. 4 (91%)
• STOT SE 3 (55.5%)
• Repr. 2 (10%)
• STOT RE 2 (12%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.