Description

2-Chloro-3-iodopyridin-4-amine (CAS No. 909036-46-0) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₄ClIN₂. This compound features a reactive chloro and iodo substituent on the pyridine ring, making it a versatile intermediate for pharmaceutical and agrochemical synthesis. Its 4-amine group enhances nucleophilic reactivity, enabling selective functionalization in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic substitutions. Ideal for researchers developing kinase inhibitors, heterocyclic scaffolds, or labeled compounds, this product is rigorously tested via HPLC, NMR, and mass spectrometry to ensure ≥95% purity. Supplied in amber vials under inert packaging to prevent degradation.

Properties

• CAS Number: 909036-46-0
• Complexity: 101
• IUPAC Name: 2-chloro-3-iodo-pyridin-4-amine
• InChI: InChI=1S/C5H4ClIN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9)
• InChI Key: BYVMKCHHWASQFN-UHFFFAOYSA-N
• Exact Mass: 253.91077
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.45
• SMILES: C1=CN=C(C(=C1N)I)Cl
• Topological: 38.9
• Monoisotopic Mass: 253.91077
• Synonyms: 2-chloro-3-iodopyridin-4-amine, 909036-46-0, DTXSID70640098, DTXCID90590849, 827-613-3, 2-chloro-3-iodo-4-pyridinamine, 4-Amino-2-chloro-3-iodopyridine, 2-Chloro-3-iodo-4-aminopyridine, MFCD09763660, SCHEMBL443823, 2-chloro-3-iodo-4-pyridylamine, BYVMKCHHWASQFN-UHFFFAOYSA-N, 2-chloro-3-iodopyridin-4-ylamine, BCP18369, BBL103614, SBB101452, STL557424, AKOS005073253, CS-W007227, LD-0209, SB21081, SY041724, DB-000461, 2-Chloro-3-iodopyridin-4-amine, AldrichCPR, EN300-192330

Application

2-Chloro-3-iodopyridin-4-amine serves as a key building block in medicinal chemistry for synthesizing kinase inhibitors and antiviral agents. Its halogenated pyridine core facilitates Pd-catalyzed cross-coupling reactions to construct complex heterocycles. Researchers also utilize it in radiolabeling studies due to the iodine moiety’s versatility. Applications extend to agrochemical intermediates and molecular probes for biochemical assays.

Safety and Hazards

GHS Hazard Statements

• H301 (50%): Toxic if swallowed [Danger Acute toxicity, oral]
• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H311 (50%): Toxic in contact with skin [Danger Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (50%)
• Acute Tox. 4 (50%)
• Acute Tox. 3 (50%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2A (50%)
• STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.