Description

2,5-Dibromopyridin-3-amine (CAS No. 90902-84-4) is a high-purity brominated pyridine derivative with the molecular formula C₅H₄Br₂N₂. This compound is a valuable building block in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure, featuring two bromine atoms and an amine group on a pyridine ring, enables versatile reactivity in cross-coupling reactions (e.g., Suzuki, Stille, or Buchwald-Hartwig) and nucleophilic substitutions. Our product is rigorously tested for purity (>95% by HPLC) and is supplied as a light-sensitive, off-white to beige crystalline powder. Proper storage under inert conditions is recommended to ensure stability. Suitable for research and industrial applications requiring precise brominated intermediates.

Properties

• CAS Number: 90902-84-4
• Complexity: 99
• IUPAC Name: 2,5-dibromopyridin-3-amine
• InChI: InChI=1S/C5H4Br2N2/c6-3-1-4(8)5(7)9-2-3/h1-2H,8H2
• InChI Key: VHGBUYMPBFPXQM-UHFFFAOYSA-N
• Exact Mass: 251.87207
• Molecular Formula: C5H4Br2N2
• Molecular Weight: 251.91
• SMILES: C1=C(C=NC(=C1N)Br)Br
• Topological: 38.9
• Monoisotopic Mass: 249.87412
• Synonyms: 2,5-Dibromopyridin-3-amine, 90902-84-4, 2,5-dibromo-3-pyridinamine, DTXSID20598590, DTXCID60549349, 804-617-3, 3-Amino-2,5-dibromopyridine, 2,5-Dibromo-pyridin-3-ylamine, 2,5-Dibromo-3-aminopyridine, MFCD09266224, 3-PYRIDINAMINE, 2,5-DIBROMO-, 2,5-dibromopyridin-3-ylamine, SCHEMBL202631, VHGBUYMPBFPXQM-UHFFFAOYSA-N, 2 pound not5-Dibromopyridin-3-amine, AKOS015835793, AC-6259, FD34202, HS-3000, PB32717, SY041992, DB-029534, 2,5-Dibromo-pyridin-3-ylamine, AldrichCPR, CS-0052143, EN300-107027

Application

2,5-Dibromopyridin-3-amine serves as a key intermediate in the synthesis of pharmaceutical compounds, particularly those targeting kinase inhibition or antimicrobial activity. Its dibromo-amine functionality allows for selective functionalization in medicinal chemistry workflows. Researchers also utilize it in the development of ligands for catalysis and agrochemical precursors. Handle with standard safety precautions for brominated aromatic amines.

Safety and Hazards

GHS Hazard Statements

• H301 (95%): Toxic if swallowed [Danger Acute toxicity, oral]
• H318 (95%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P270, P280, P301+P316, P305+P354+P338, P317, P321, P330, P405, and P501

Hazard Classes and Categories

• Acute Tox. 3 (95%)
• Eye Dam. 1 (95%)

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