Description

2,5-Difluoro-4-methoxyphenylboronic acid (CAS No. 897958-93-9) is a high-purity boronic acid derivative with the molecular formula C₇H₇BF₂O₃. This compound is a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, due to its stable boronic acid functional group and electron-rich aromatic system. The presence of fluorine and methoxy substituents enhances its reactivity and selectivity in palladium-catalyzed transformations. Ideal for pharmaceutical, agrochemical, and materials science research, this product is rigorously tested for purity (typically ≥95% by HPLC or NMR) and is supplied as a white to off-white crystalline powder. Store under inert conditions at 2-8°C to ensure long-term stability.

Properties

• CAS Number: 897958-93-9
• Complexity: 170
• IUPAC Name: (2,5-difluoro-4-methoxy-phenyl)boronic acid
• InChI: InChI=1S/C7H7BF2O3/c1-13-7-3-5(9)4(8(11)12)2-6(7)10/h2-3,11-12H,1H3
• InChI Key: BRMUXDWCSVTVPQ-UHFFFAOYSA-N
• Exact Mass: 188.0456306
• Molecular Formula: C7H7BF2O3
• Molecular Weight: 187.94
• SMILES: B(C1=CC(=C(C=C1F)OC)F)(O)O
• Topological: 49.7
• Monoisotopic Mass: 188.0456306
• Synonyms: 2,5-Difluoro-4-methoxyphenylboronic acid, 897958-93-9, (2,5-difluoro-4-methoxyphenyl)boronic acid, 2,5-DIFLUORO-4-METHOXYBENZENEBORONIC ACID, (2,5-difluoro-4-methoxy-phenyl)boronic Acid, MFCD04038754, SCHEMBL789623, DTXSID90395179, BRMUXDWCSVTVPQ-UHFFFAOYSA-N, SBB071158, AKOS006344713, AB17187, AS-33366, (2,5-difluoro-4-methoxyphenyl)boronicacid, DB-010717, CS-0176113, [2,5-difluoro-4-(methyloxy)phenyl]boronic acid

Application

2,5-Difluoro-4-methoxyphenylboronic acid is widely used as a key intermediate in the synthesis of bioactive molecules, including pharmaceuticals and agrochemicals. Its boronic acid moiety facilitates Suzuki-Miyaura cross-coupling reactions to form biaryl structures, common in drug discovery. The electron-withdrawing fluorine atoms and electron-donating methoxy group make it valuable for tuning electronic properties in conjugated materials. Researchers also employ it in the development of sensors and catalysts due to its unique steric and electronic profile.

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