Description

5-Chloro-2,3-difluoropyridine (CAS No. 89402-43-7) is a high-purity fluorinated pyridine derivative with the molecular formula C₅H₂ClF₂N. This heterocyclic compound is characterized by its chloro and difluoro substitutions at the 5, 2, and 3 positions, respectively, making it a versatile intermediate in pharmaceutical and agrochemical synthesis. Its precise molecular structure ensures excellent reactivity in cross-coupling reactions, nucleophilic substitutions, and other functionalization processes. Packaged under inert conditions to maintain stability, this compound is ideal for research and industrial applications requiring stringent quality standards. Available in quantities ranging from grams to kilograms, it is supplied with comprehensive analytical data (including GC/MS, NMR, and HPLC) to guarantee purity and consistency.

Properties

• CAS Number: 89402-43-7
• Complexity: 101
• IUPAC Name: 5-chloro-2,3-difluoro-pyridine
• InChI: InChI=1S/C5H2ClF2N/c6-3-1-4(7)5(8)9-2-3/h1-2H
• InChI Key: PERMDYZFNQIKBL-UHFFFAOYSA-N
• Exact Mass: 148.9843831
• Molecular Formula: C5H2ClF2N
• Molecular Weight: 149.52
• SMILES: C1=C(C=NC(=C1F)F)Cl
• Topological: 12.9
• Monoisotopic Mass: 148.9843831
• Synonyms: 5-Chloro-2,3-difluoropyridine, 89402-43-7, 2,3-Difluoro-5-chloropyridine, NTR2GM7GHF, EC 410-090-7, DTXSID001008801, Pyridine, 5-chloro-2,3-difluoro-, DTXCID001435632, 410-090-7, 618-273-5, MFCD04039314, 2,3-DIFLUORO-5-CHLORO PYRIDINE, 589402-43-7, 2,3-Difluoro-5-chloropyridine; 3-Chloro-5,6-difluoropyridine;, 3-chloro-5,6-difluoropyridine, 5-chloro-2,3-difluoro-pyridine, UNII-NTR2GM7GHF, SCHEMBL47044, SBB086666, AKOS005064057, 2,3-Difluoro-5-chloropyridine, 95%, AC-8181, CS-W003144, FG-0488, AC-23446, DB-027547, DB-292156, C2113, NS00005305, ST50824183, EN300-98067, Z1255442949

Application

5-Chloro-2,3-difluoropyridine serves as a key building block in the synthesis of advanced pharmaceutical compounds, particularly in the development of kinase inhibitors and antimicrobial agents. Its fluorinated pyridine core is instrumental in agrochemical research for creating novel herbicides and pesticides with enhanced activity. The compound’s reactivity also makes it valuable in material science for designing fluorinated liquid crystals or electronic materials.

Safety and Hazards

GHS Hazard Statements

• H226: Flammable liquid and vapor [Warning Flammable liquids]
• H302: Harmful if swallowed [Warning Acute toxicity, oral]
• H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

Precautionary Statements

• P210, P233, P240, P241, P242, P243, P264, P270, P273, P280, P301+P317, P303+P361+P353, P330, P370+P378, P403+P235, and P501

Hazard Classes and Categories

• Flam. Liq. 3 (100%)
• Acute Tox. 4 (98.8%)
• Aquatic Chronic 3 (98.8%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.