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Atomfair 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine C12H19BN2O3 CAS 893440-50-1

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (CAS: 893440-50-1) is a high-purity boronic ester derivative, widely used as a key intermediate in organic synthesis and pharmaceutical research. This compound features a pyridine core functionalized with a methoxy group, an amine group, and a pinacol boronate ester, making it highly versatile for Suzuki-Miyaura cross-coupling reactions. Its molecular formula is C12H19BN2O3, and it is supplied as a white to off-white crystalline powder with exceptional stability under inert conditions. Ideal for researchers in medicinal chemistry, this reagent enables efficient construction of complex heterocyclic scaffolds. Each batch undergoes rigorous QC testing (HPLC, NMR) to ensure ≥95% purity, meeting the stringent…

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Description

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine (CAS: 893440-50-1) is a high-purity boronic ester derivative, widely used as a key intermediate in organic synthesis and pharmaceutical research. This compound features a pyridine core functionalized with a methoxy group, an amine group, and a pinacol boronate ester, making it highly versatile for Suzuki-Miyaura cross-coupling reactions. Its molecular formula is C12H19BN2O3, and it is supplied as a white to off-white crystalline powder with exceptional stability under inert conditions. Ideal for researchers in medicinal chemistry, this reagent enables efficient construction of complex heterocyclic scaffolds. Each batch undergoes rigorous QC testing (HPLC, NMR) to ensure ≥95% purity, meeting the stringent demands of academic and industrial laboratories.

Properties

  • CAS Number: 893440-50-1
  • Complexity: 296
  • IUPAC Name: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine
  • InChI: InChI=1S/C12H19BN2O3/c1-11(2)12(3,4)18-13(17-11)8-6-9(14)10(16-5)15-7-8/h6-7H,14H2,1-5H3
  • InChI Key: KYYKGOURQXPERA-UHFFFAOYSA-N
  • Exact Mass: 250.1488726
  • Molecular Formula: C12H19BN2O3
  • Molecular Weight: 250.10
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC(=C(N=C2)OC)N
  • Topological: 66.6
  • Monoisotopic Mass: 250.1488726
  • Synonyms: 893440-50-1, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-amine, DTXSID90732383, DTXCID70683127, 811-804-3, 5-Amino-6-methoxypyridine-3-boronic acid pinacol ester, 3-Amino-2-methoxypyridine-5-boronic acid pinacol ester, dioxaborolan-2-yl)-pyridin-3-ylamine, 2-Methoxy-3-aminopyridine-5-boronic acid pinacol ester, 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2], 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridin-3-ylamine, MFCD12923427, (5-amino-6-methoxypyridin-3-yl)boronic acid pinacol ester, 5-Amino-6-methoxypyridine-3-boronicAcidPinacolEster, 3-Amino-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, SCHEMBL110292, KYYKGOURQXPERA-UHFFFAOYSA-N, CS-B1261, AKOS016009440, DS-2761, AC-33298, SY046718, A2993, EN300-7412473, Z1419254557, 2-(5-Amino-6-methoxy-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, 2-METHOXY-5-(TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-AMINE, 2-(methoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine, 2-(Methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinamine, 2-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-3-ylamine, 3-Amino-2-methoxy-5-(4,4,5,5-tetramethyl[1,3,2-dioxaborolan-2-yl)pyridine, 3-Amino-2-methoxy-5-(4,4,5,5-tetramethyl[1,3,2-dioxaborolan-2-yl)pyridine…

This compound is primarily employed in palladium-catalyzed cross-coupling reactions to introduce boronic acid functionality into target molecules. It serves as a critical building block for synthesizing drug candidates, particularly in kinase inhibitor development. Researchers utilize it to create structurally diverse pyridine derivatives for high-throughput screening. The pinacol boronate group enhances stability while maintaining reactivity in aqueous conditions.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (75%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (75%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

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  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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