Description

2,5-Dichloropyridine-4-carboxylic Acid (CAS No. 88912-26-9) is a high-purity heterocyclic compound with the molecular formula C₆H₃Cl₂NO₂. This versatile intermediate is widely used in pharmaceutical synthesis, agrochemical development, and material science research. The compound features a pyridine ring substituted with two chlorine atoms at the 2 and 5 positions and a carboxylic acid group at the 4 position, offering multiple reactive sites for further functionalization. Our product is supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), ideal for demanding synthetic applications. Proper handling requires PPE due to potential irritant properties. Each batch undergoes rigorous QC testing including NMR, HPLC, and mass spectrometry to ensure consistency and reliability for your research needs.

Properties

• CAS Number: 88912-26-9
• Complexity: 165
• IUPAC Name: 2,5-dichloropyridine-4-carboxylic acid
• InChI: InChI=1S/C6H3Cl2NO2/c7-4-2-9-5(8)1-3(4)6(10)11/h1-2H,(H,10,11)
• InChI Key: GFOVTTQVBDEYPP-UHFFFAOYSA-N
• Exact Mass: 190.9540837
• Molecular Formula: C6H3Cl2NO2
• Molecular Weight: 192.00
• SMILES: C1=C(C(=CN=C1Cl)Cl)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 190.9540837
• Synonyms: 2,5-Dichloroisonicotinic acid, 88912-26-9, 2,5-dichloropyridine-4-carboxylic Acid, GFOVTTQVBDEYPP-UHFFFAOYSA-, DTXSID10371117, DTXCID80322151, 679-892-4, inchi=1/c6h3cl2no2/c7-4-2-9-5(8)1-3(4)6(10)11/h1-2h,(h,10,11), 2,5-dichloro-4-pyridinecarboxylic acid, MFCD00466640, 2,5-dichloro-isonicotinic acid, 2,5-Dichloroisonicotinicacid, 4-PYRIDINECARBOXYLIC ACID, 2,5-DICHLORO-, SCHEMBL1300053, GFOVTTQVBDEYPP-UHFFFAOYSA-N, BBL102333, SBB065260, STL556133, AKOS005070293, AB06268, AC-3586, CS-W002633, SY007561, DB-008136, D2599, EN300-93715, 2,5-Dichloropyridine-4-carboxylic acid, 95%, 3W-0027, Z1255450473

This compound serves as a key building block in medicinal chemistry for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and antimicrobial agents. Researchers utilize it as a precursor for creating more complex heterocyclic systems through nucleophilic substitution reactions at the chloro positions. In material science, it finds application in the preparation of functionalized polymers and coordination complexes. The carboxylic acid moiety allows for easy conjugation to other molecules via amide coupling or esterification reactions.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.