Description

5-Bromo-3-methylpyridine-2-carboxylic acid (CAS No. 886365-43-1) is a high-purity heterocyclic organic compound with the molecular formula C₇H₆BrNO₂. This white to off-white crystalline powder is a versatile intermediate in pharmaceutical and agrochemical synthesis, offering excellent reactivity for functionalization at the bromine and carboxylic acid sites. With a molecular weight of 216.03 g/mol, this compound is characterized by its pyridine core substituted with a bromo group at the 5-position, a methyl group at the 3-position, and a carboxylic acid at the 2-position. Our product is rigorously tested via HPLC, NMR, and mass spectrometry to ensure ≥98% purity, making it ideal for research in medicinal chemistry, ligand design, and cross-coupling reactions. Packaged under inert gas in amber glass vials to ensure stability.

Properties

• CAS Number: 886365-43-1
• Complexity: 163
• IUPAC Name: 5-bromo-3-methyl-pyridine-2-carboxylic acid
• InChI: InChI=1S/C7H6BrNO2/c1-4-2-5(8)3-9-6(4)7(10)11/h2-3H,1H3,(H,10,11)
• InChI Key: GSOCTKHBFREQCV-UHFFFAOYSA-N
• Exact Mass: 214.95819
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.03
• SMILES: CC1=CC(=CN=C1C(=O)O)Br
• Topological: 50.2
• Monoisotopic Mass: 214.95819
• Synonyms: 886365-43-1, 5-Bromo-3-methylpyridine-2-carboxylic acid, DTXSID50672014, DTXCID20622763, 689-115-0, 5-Bromo-2-Carboxy-3-Methylpyridine, 5-bromo-3-methylpicolinic acid, 5-Bromo-3-methyl-pyridine-2-carboxylic acid, MFCD07375125, 2-Pyridinecarboxylicacid, 5-bromo-3-methyl-, 5-bromo-3-methylpicolinicacid, SCHEMBL361806, GSOCTKHBFREQCV-UHFFFAOYSA-N, SBB052958, AKOS015834424, AB41227, CS-W003404, FS-2438, SY018925, EN300-103943, Z1269174153

Application

5-Bromo-3-methylpyridine-2-carboxylic acid serves as a key building block in Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery. It is widely used in the synthesis of kinase inhibitors and receptor modulators due to its metal-coordinating pyridine moiety. The compound also finds applications in material science as a precursor for functionalized ligands in catalytic systems.

Safety and Hazards

GHS Hazard Statements

• H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (50%)
• Acute Tox. 4 (50%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• Acute Tox. 4 (50%)
• STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.