Description

5-Bromo-4-methylpyridine-2-carboxylic acid (CAS No. 886365-02-2) is a high-purity heterocyclic carboxylic acid derivative with the molecular formula C₇H₆BrNO₂. This compound features a bromo-substituted pyridine ring with a methyl group at the 4-position and a carboxylic acid moiety at the 2-position, making it a versatile building block for pharmaceutical, agrochemical, and material science research. Its molecular weight is 216.03 g/mol, and it is supplied as a fine white to off-white crystalline powder with ≥95% purity (HPLC). Ideal for coupling reactions, metal-catalyzed cross-coupling, and ligand synthesis, this reagent is packaged under inert conditions to ensure stability. Available in quantities from milligrams to kilograms, it is suitable for lab-scale and industrial applications. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 886365-02-2
• Complexity: 163
• IUPAC Name: 5-bromo-4-methyl-pyridine-2-carboxylic acid
• InChI: InChI=1S/C7H6BrNO2/c1-4-2-6(7(10)11)9-3-5(4)8/h2-3H,1H3,(H,10,11)
• InChI Key: RMSVDYVOLGRLNJ-UHFFFAOYSA-N
• Exact Mass: 214.95819
• Molecular Formula: C7H6BrNO2
• Molecular Weight: 216.03
• SMILES: CC1=CC(=NC=C1Br)C(=O)O
• Topological: 50.2
• Monoisotopic Mass: 214.95819
• Synonyms: 5-Bromo-4-methylpyridine-2-carboxylic acid, 886365-02-2, DTXSID90672174, DTXCID00622923, 692-871-4, 5-Bromo-4-methylpicolinic acid, MFCD07375100, 5-Bromo-2-carboxy-4-methylpyridine, 5-bromo-4-methyl-pyridine-2-carboxylic acid, 5-BROMO-4-METHYL-2-PYRIDINECARBOXYLIC ACID, 5-Bromo-4-methylpyridine-2-carboxylicacid, SCHEMBL1180456, RMSVDYVOLGRLNJ-UHFFFAOYSA-N, CS-D1645, AKOS015919950, AB41173, FS-3082, DA-19296, SY031506, EN300-139940

Application

5-Bromo-4-methylpyridine-2-carboxylic acid is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. It serves as a precursor for Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to construct complex heterocyclic scaffolds. Researchers also employ it in the development of kinase inhibitors, antimicrobial agents, and functionalized ligands for catalysis. Its carboxylic acid group allows for further derivatization via amidation or esterification.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Acute Tox. 4 (100%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (100%)
• STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.