Description

5-Bromo-2-methoxypyridin-3-amine (CAS No. 884495-39-0) is a high-purity heterocyclic compound with the molecular formula C₆H₇BrN₂O, widely utilized in pharmaceutical research, agrochemical synthesis, and organic chemistry applications. This versatile intermediate features a bromine substituent at the 5-position and a methoxy group at the 2-position of the pyridine ring, enabling selective functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig). Its crystalline solid form (typically white to off-white) ensures consistent reactivity, with HPLC purity ≥95% (GC/MS verified). Ideal for constructing complex scaffolds in drug discovery, this compound is packaged under inert gas to enhance stability and shipped with comprehensive analytical data (NMR, LC-MS).

Properties

• CAS Number: 884495-39-0
• Complexity: 112
• IUPAC Name: 5-bromo-2-methoxy-pyridin-3-amine
• InChI: InChI=1S/C6H7BrN2O/c1-10-6-5(8)2-4(7)3-9-6/h2-3H,8H2,1H3
• InChI Key: HJOOFLFWIISCAI-UHFFFAOYSA-N
• Exact Mass: 201.97418
• Molecular Formula: C6H7BrN2O
• Molecular Weight: 203.04
• SMILES: COC1=C(C=C(C=N1)Br)N
• Topological: 48.1
• Monoisotopic Mass: 201.97418
• Synonyms: 5-bromo-2-methoxypyridin-3-amine, 884495-39-0, DTXSID80660560, DTXCID70611309, 804-695-9, 3-Amino-5-bromo-2-methoxypyridine, 5-bromo-2-methoxy-3-pyridinamine, MFCD07368887, 5-BROMO-2-METHOXY-3-AMINOPYRIDINE, 5-BROMO-2-(METHYLOXY)-3-PYRIDINAMINE, EN300-61899, SCHEMBL112761, HJOOFLFWIISCAI-UHFFFAOYSA-N, 5-bromo-2-methoxy-3-pyridylamine, BDBM626192, CS-M0124, 2-methoxy-3-amino-5-bromo pyridine, BBL101326, SBB093040, STL555122, AKOS005073254, AC-9847, LD-0211, PB15873, SB10497, BL007596, SY022291, DB-025039, DB-082193, 5-Bromo-2-methoxypyridin-3-amine, AldrichCPR

5-Bromo-2-methoxypyridin-3-amine serves as a key building block in medicinal chemistry for synthesizing kinase inhibitors and receptor modulators. Its reactive bromo and amino groups facilitate Pd-catalyzed couplings to generate biaryl or heteroaryl derivatives. Researchers employ it in high-throughput screening libraries due to its balanced lipophilicity (LogP ~1.8) and metabolic stability. The methoxy group enhances electron density, directing electrophilic substitutions in follow-up reactions.

Safety and Hazards

GHS Hazard Statements

• H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H317 (97.6%): May cause an allergic skin reaction [Warning Sensitization, Skin]
• H318 (97.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.6%)
• Skin Irrit. 2 (100%)
• Skin Sens. 1 (97.6%)
• Eye Dam. 1 (97.6%)
• STOT SE 3 (97.6%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.