Description

3-Bromo-5-fluoro-2-methoxypyridine (CAS No. 884494-81-9) is a high-purity halogenated pyridine derivative with the molecular formula C₆H₅BrFNO. This compound is a valuable building block in pharmaceutical and agrochemical synthesis, featuring a bromo- and fluoro-substituted pyridine core with a methoxy functional group at the 2-position. Its unique structure enables versatile reactivity in cross-coupling reactions, nucleophilic substitutions, and metal-catalyzed transformations. Supplied as a crystalline solid with ≥95% purity (HPLC), it is rigorously tested for consistency via GC-MS, NMR, and elemental analysis. Packaged under inert gas in amber glass vials to ensure stability, this reagent is ideal for research in medicinal chemistry, materials science, and specialty chemical development. Synonyms include DTXSID30654217 and DTXCID60604967.

Properties

• CAS Number: 884494-81-9
• Complexity: 114
• IUPAC Name: 3-bromo-5-fluoro-2-methoxy-pyridine
• InChI: InChI=1S/C6H5BrFNO/c1-10-6-5(7)2-4(8)3-9-6/h2-3H,1H3
• InChI Key: HSWCOAGQYSBFAK-UHFFFAOYSA-N
• Exact Mass: 204.95385
• Molecular Formula: C6H5BrFNO
• Molecular Weight: 206.01
• SMILES: COC1=C(C=C(C=N1)F)Br
• Topological: 22.1
• Monoisotopic Mass: 204.95385
• Synonyms: 3-bromo-5-fluoro-2-methoxypyridine, 884494-81-9, DTXSID30654217, DTXCID60604967, 832-604-2, MFCD04972397, 3-bromo-5-fluoro-2-methoxy-pyridine, 2-METHOXY-3-BROMO-5-FLUOROPYRIDINE, SCHEMBL933336, HSWCOAGQYSBFAK-UHFFFAOYSA-N, BCP23394, 5-Fluoro-3-bromo-2-methoxypyridine, AKOS005145878, CS-W003209, AC-33410, FB105388, SY022326, DB-024953, B5134, EN300-1697317

Application

3-Bromo-5-fluoro-2-methoxypyridine serves as a key intermediate in Suzuki-Miyaura and Buchwald-Hartwig couplings for drug discovery. Its electron-deficient pyridine ring facilitates the synthesis of kinase inhibitors and fluorinated bioactive molecules. The compound is also employed in material science for creating functionalized heterocycles in OLED and semiconductor research.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (25%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (75%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (75%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (25%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (75%)
• Acute Tox. 4 (75%)
• Skin Irrit. 2 (50%)
• Eye Irrit. 2A (50%)
• Acute Tox. 4 (75%)
• STOT SE 3 (25%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.