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Atomfair 6-Chloro-3-fluoro-2-methylpyridine C6H5ClFN CAS 884494-78-4

6-Chloro-3-fluoro-2-methylpyridine (CAS No. 884494-78-4) is a high-purity halogenated pyridine derivative with the molecular formula C6H5ClFN . This compound is a valuable building block in pharmaceutical and agrochemical synthesis, featuring a unique combination of chloro, fluoro, and methyl substituents on its pyridine ring. Its precise molecular structure (IUPAC name: 6-chloro-3-fluoro-2-methylpyridine) enables selective reactivity for advanced heterocyclic chemistry applications. Available in >98% purity (HPLC), this product is rigorously tested by GC/MS and1H NMR to meet research-grade standards. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for active pharmaceutical ingredients (APIs). Packaged under inert gas in amber glass vials…

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Description

6-Chloro-3-fluoro-2-methylpyridine (CAS No. 884494-78-4) is a high-purity halogenated pyridine derivative with the molecular formula C6H5ClFN. This compound is a valuable building block in pharmaceutical and agrochemical synthesis, featuring a unique combination of chloro, fluoro, and methyl substituents on its pyridine ring. Its precise molecular structure (IUPAC name: 6-chloro-3-fluoro-2-methylpyridine) enables selective reactivity for advanced heterocyclic chemistry applications. Available in >98% purity (HPLC), this product is rigorously tested by GC/MS and 1H NMR to meet research-grade standards. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a precursor for active pharmaceutical ingredients (APIs). Packaged under inert gas in amber glass vials with certified concentration for batch-to-batch consistency.

Properties

  • CAS Number: 884494-78-4
  • Complexity: 99.1
  • IUPAC Name: 6-chloro-3-fluoro-2-methyl-pyridine
  • InChI: InChI=1S/C6H5ClFN/c1-4-5(8)2-3-6(7)9-4/h2-3H,1H3
  • InChI Key: ICSRNKKGNHKSJH-UHFFFAOYSA-N
  • Exact Mass: 145.0094550
  • Molecular Formula: C6H5ClFN
  • Molecular Weight: 145.56
  • SMILES: CC1=C(C=CC(=N1)Cl)F
  • Topological: 12.9
  • Monoisotopic Mass: 145.0094550
  • Synonyms: 6-chloro-3-fluoro-2-methylpyridine, 884494-78-4, DTXSID60600803, DTXCID40551561, 2-Chloro-5-fluoro-6-methylpyridine, 2-chloro-5-fluoro-6-picoline, MFCD04972391, 917835-67-7, SCHEMBL247652, ICSRNKKGNHKSJH-UHFFFAOYSA-N, BCP23371, SBB086437, AKOS005145877, CS-W009124, GS-6912, PB43697, SY017449, 6-chloranyl-3-fluoranyl-2-methyl-pyridine, DB-006064, EN300-113734, A842597

Application

6-Chloro-3-fluoro-2-methylpyridine serves as a key intermediate in the synthesis of novel fluorinated pyridine compounds for crop protection chemicals. Its reactive halogen sites enable efficient Suzuki-Miyaura and Buchwald-Hartwig couplings in drug discovery programs targeting kinase inhibitors. The electron-deficient pyridine core facilitates heteroaromatic substitutions in material science applications. Researchers utilize this compound to develop PET radiotracers due to its fluorine moiety.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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