Description

2-Chloro-5-fluoro-4-iodopyridine (CAS No. 884494-49-9) is a high-purity halogenated pyridine derivative designed for advanced research and pharmaceutical applications. This compound features a unique molecular structure (C₅H₂ClFIN) with chlorine, fluorine, and iodine substituents, offering exceptional reactivity for cross-coupling reactions, nucleophilic substitutions, and heterocyclic synthesis. Ideal for medicinal chemistry, agrochemical development, and material science research. Packaged under inert atmosphere to ensure stability, with batch-specific COA and ¹H/¹³C NMR data available upon request. Available in 1g, 5g, and 25g amber glass vials with optional argon-sealed packaging for sensitive applications.

Properties

• CAS Number: 884494-49-9
• Complexity: 103
• IUPAC Name: 2-chloro-5-fluoro-4-iodo-pyridine
• InChI: InChI=1S/C5H2ClFIN/c6-5-1-4(8)3(7)2-9-5/h1-2H
• InChI Key: CRLPRXQOSARJCF-UHFFFAOYSA-N
• Exact Mass: 256.89045
• Molecular Formula: C5H2ClFIN
• Molecular Weight: 257.43
• SMILES: C1=C(C(=CN=C1Cl)F)I
• Topological: 12.9
• Monoisotopic Mass: 256.89045
• Synonyms: 2-chloro-5-fluoro-4-iodopyridine, 884494-49-9, DTXSID50647540, DTXCID60598291, 800-457-3, MFCD03095306, 2-chloro-4-iodo-5-fluoropyridine, Pyridine, 2-chloro-5-fluoro-4-iodo-, SCHEMBL359435, 2-chloro-5-fluoro-4-iodpyridine, CRLPRXQOSARJCF-UHFFFAOYSA-N, BBL102564, STL556367, AKOS005259148, AB13669, CS-W000348, AC-27893, AC-33398, AS-18586, SY022338, DB-024978, EN300-154630

Application

2-Chloro-5-fluoro-4-iodopyridine serves as a versatile building block in Suzuki-Miyaura and Stille coupling reactions for pharmaceutical intermediates. Its electron-deficient pyridine core facilitates nucleophilic aromatic substitutions in agrochemical synthesis. Researchers utilize this compound to develop fluorinated bioactive molecules and PET radiotracer precursors.

Safety and Hazards

GHS Hazard Statements

• H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (80%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (20%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (40%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (80%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (100%)
• Skin Irrit. 2 (80%)
• Eye Irrit. 2A (60%)
• Acute Tox. 4 (40%)
• STOT SE 3 (80%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.