Atomfair 2-Amino-3-bromo-5-fluoropyridine C5H4BrFN2 CAS 869557-43-7

Description

2-Amino-3-bromo-5-fluoropyridine (CAS No. 869557-43-7) is a high-purity halogenated pyridine derivative with the molecular formula C₅H₄BrFN₂. This compound, also known by its IUPAC name 3-bromo-5-fluoropyridin-2-amine, is a versatile building block in pharmaceutical and agrochemical research. Its unique structure, featuring both bromo and fluoro substituents on the pyridine ring, makes it an ideal intermediate for nucleophilic aromatic substitution reactions, cross-coupling reactions, and other functional group transformations. This product is synthesized under strict quality control measures to ensure ≥95% purity (HPLC) and is supplied as a white to off-white crystalline powder. It is packaged under inert gas to maintain stability and is ideal for use in medicinal chemistry, material science, and as a ligand precursor in catalysis. Store in a cool, dry place away from light and moisture.

Properties

• CAS Number: 869557-43-7
• Complexity: 101
• IUPAC Name: 3-bromo-5-fluoro-pyridin-2-amine
• InChI: InChI=1S/C5H4BrFN2/c6-4-1-3(7)2-9-5(4)8/h1-2H,(H2,8,9)
• InChI Key: KXSQMCRVUAALNE-UHFFFAOYSA-N
• Exact Mass: 189.95419
• Molecular Formula: C5H4BrFN2
• Molecular Weight: 191.00
• SMILES: C1=C(C=NC(=C1Br)N)F
• Topological: 38.9
• Monoisotopic Mass: 189.95419
• Synonyms: 2-Amino-3-bromo-5-fluoropyridine, 3-BROMO-5-FLUORO-2-PYRIDINAMINE, 675-556-6, 869557-43-7, 3-bromo-5-fluoropyridin-2-amine, 3-bromo-5-fluoro-pyridin-2-ylamine, MFCD03092924, EN300-99165, 2-PYRIDINAMINE, 3-BROMO-5-FLUORO-, 3-bromo-5-fluoro-2-pyridylamine, SCHEMBL473753, DTXSID80583124, KXSQMCRVUAALNE-UHFFFAOYSA-N, BDBM626235, BBL100754, SBB051864, STL554548, 3-bromo-5-fluoro-pyridine-2-ylamine, AKOS005137899, AC-9415, CS-W010739, HY-W010023, PS-8361, 2-Amino-3-bromo-5-fluoropyridine, 97%, SY064360, DB-031373, A3346, Z1201621986, 2-Amino-5-fluoro-3-bromopyridine;3-bromo-5-fluoro-2-Aminopyridine;3-Bromo-2-amino-5-fluoropyridine;5-Fluoro-2-amino-3-bromopyridine;5-Fluoro-3-bromo-2-aminopyridine

Application

2-Amino-3-bromo-5-fluoropyridine is widely used as a key intermediate in the synthesis of biologically active compounds, particularly in the development of pharmaceuticals and agrochemicals. Its reactive bromo and amino groups enable efficient derivatization for the construction of complex heterocyclic scaffolds. Researchers utilize this compound in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to access novel pyridine-based drug candidates. It is also employed in the preparation of fluorinated analogs for metabolic stability studies in medicinal chemistry programs.

Safety and Hazards

GHS Hazard Statements

• H302 (95.1%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H318 (95.1%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
• H335 (97.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (95.1%)
• Skin Irrit. 2 (100%)
• Eye Dam. 1 (95.1%)
• STOT SE 3 (97.6%)

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