Description
8-Fluoro-3-iodoquinoline (CAS No. 866782-59-4) is a high-purity halogenated quinoline derivative designed for advanced research and pharmaceutical applications. This compound features a molecular formula of C9H5FIN and a precise molecular weight of 273.05 g/mol. Its unique structure, combining a fluorine substituent at the 8-position and an iodine atom at the 3-position of the quinoline core, makes it a valuable intermediate in medicinal chemistry, particularly in the synthesis of bioactive molecules and fluorinated heterocycles.
Our product is rigorously tested for quality, ensuring ≥95% purity (HPLC) and optimal stability under recommended storage conditions (2-8°C, protected from light). Ideal for cross-coupling reactions, such as Suzuki-Miyaura or Sonogashira couplings, this reagent is supplied in amber glass vials to prevent degradation. Researchers can rely on its consistent performance in drug discovery, agrochemical development, and material science applications.
Properties
- CAS Number: 866782-59-4
- Complexity: 165
- IUPAC Name: 8-fluoro-3-iodo-quinoline
- InChI: InChI=1S/C9H5FIN/c10-8-3-1-2-6-4-7(11)5-12-9(6)8/h1-5H
- InChI Key: PFDRCQPNBZLTJQ-UHFFFAOYSA-N
- Exact Mass: 272.94507
- Molecular Formula: C9H5FIN
- Molecular Weight: 273.05
- SMILES: C1=CC2=CC(=CN=C2C(=C1)F)I
- Topological: 12.9
- Monoisotopic Mass: 272.94507
- Synonyms: 8-Fluoro-3-iodoquinoline, 866782-59-4, DTXSID20585324, DTXCID30536089, 617-904-1, 8-Fluoro-3-iodo-quinoline, MFCD07700291, Quinoline, 8-fluoro-3-iodo-, SCHEMBL1666214, SCHEMBL1925454, PFDRCQPNBZLTJQ-UHFFFAOYSA-N, AKOS016012956, SB39178, SY124025, DB-076705, CS-0102162, EN300-80134, Z1218936328
Application
8-Fluoro-3-iodoquinoline serves as a versatile building block in pharmaceutical research, particularly for synthesizing fluorinated quinoline-based drug candidates. Its iodine moiety facilitates palladium-catalyzed cross-coupling reactions, enabling the construction of complex molecular architectures. This compound is also employed in the development of fluorescent probes and optoelectronic materials due to its conjugated quinoline scaffold.
Safety and Hazards
GHS Hazard Statements
- H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
- H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
- H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
- H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statements
- P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Hazard Classes and Categories
- Acute Tox. 4 (100%)
- Skin Irrit. 2 (100%)
- Eye Irrit. 2A (100%)
- STOT SE 3 (100%)
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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.
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