Description

1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid (CAS No. 849217-48-7) is a high-purity organic compound with the molecular formula C₁₁H₁₀FNO₃. This cyclopropane derivative features a fluorophenyl carbamoyl group and a carboxylic acid functionality, making it a valuable intermediate for pharmaceutical and agrochemical research. Its well-defined structure (IUPAC name: 1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid) ensures consistent reactivity in synthetic applications. Supplied as a white to off-white crystalline powder with ≥95% purity (HPLC), it is ideal for medicinal chemistry, structure-activity relationship (SAR) studies, and scaffold diversification. Packaged under inert gas with batch-specific COA, this compound is stored at 2-8°C to ensure stability.

Properties

• CAS Number: 849217-48-7
• Complexity: 306
• IUPAC Name: 1-[(4-fluorophenyl)carbamoyl]cyclopropanecarboxylic acid
• InChI: InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
• InChI Key: PFMAFXYUHZDKPY-UHFFFAOYSA-N
• Exact Mass: 223.06447134
• Molecular Formula: C11H10FNO3
• Molecular Weight: 223.20
• SMILES: C1CC1(C(=O)NC2=CC=C(C=C2)F)C(=O)O
• Topological: 66.4
• Monoisotopic Mass: 223.06447134
• Synonyms: 849217-48-7, 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid, 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid, 1-[(4-fluorophenyl)carbamoyl]cyclopropanecarboxylic acid, 8P43N3DM5Y, Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)amino]carbonyl]-, 1-(((4-Fluorophenyl)amino)carbonyl)cyclopropanecarboxylic acid, Cyclopropanecarboxylic acid, 1-(((4-fluorophenyl)amino)carbonyl)-, 1-{[(4-fluorophenyl)amino]carbonyl}cyclopropanecarboxylic acid, 834-548-4, 1-[(4-fluorophenyl)carbamoyl]cyclopropane-1-carboxylic acid, MFCD11226313, 1-(4-fluoro-phenylcarbamoyl)-cyclopropanecarboxylic acid, 1-(4-fluoro-phenylcarbamoyl}-cyclopropanecarboxylic acid, 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic Acid;Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)amino]carbonyl]- (9CI, ACI); 1-[[(4-Fluorophenyl)amino]carbonyl]cyclopropanecarboxylic acid (ACI); 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid, InterMediate of Cabozantinib, UNII-8P43N3DM5Y, SCHEMBL105644, 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylicacid, DTXSID00610608, BCP15333, AKOS008151310, CS-W019220, SB17898, AC-29722, DS-14316, SY047869, DB-345082, F1083, EN300-58849, ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid, 1-(4-fluorophenylcarbamoyl)-cyclopropanecarboxylic acid, Z877368600, 1-((4-fluorophenyl)carbamoyl) -cyclopropanecarboxylic acid, 1-((4-fluorophenyl)carbamoyl) cyclopropanecarboxylic acid, 1-((4-fluorophenyl)carbamoyl)-cyclopropanecarboxylic acid, 1-((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid, 1-(4-fluorophenylaminocarbonyl)cyclopropanecarboxylic acid

Application

This compound serves as a key building block in the synthesis of biologically active molecules, particularly in developing kinase inhibitors and GPCR-targeted therapeutics. Its cyclopropane scaffold enhances metabolic stability in drug candidates, while the fluorophenyl group contributes to binding affinity. Researchers utilize it for fragment-based drug design and as a precursor in peptidomimetic chemistry.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statements

• P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)

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