Description

1-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 847818-74-0) is a high-purity boronic ester derivative widely used in organic synthesis, pharmaceutical research, and materials science. This compound features a stable pinacol boronate group, making it an essential reagent for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry. With a molecular formula of C₁₀H₁₇BN₂O₂, it offers excellent solubility in common organic solvents such as THF, DMF, and dichloromethane, ensuring compatibility with diverse reaction conditions. Our product is rigorously tested for purity (≥97% by HPLC) and is supplied in sealed packaging under inert gas to ensure stability and longevity. Ideal for researchers and industrial chemists seeking reliable boron-containing intermediates for drug discovery and advanced material development.

Properties

• CAS Number: 847818-74-0
• Complexity: 242
• IUPAC Name: 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
• InChI: InChI=1S/C10H17BN2O2/c1-9(2)10(3,4)15-11(14-9)8-6-7-12-13(8)5/h6-7H,1-5H3
• InChI Key: HLXOVAMYQUFLPE-UHFFFAOYSA-N
• Exact Mass: 208.1383080
• Molecular Formula: C10H17BN2O2
• Molecular Weight: 208.07
• SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=NN2C
• Topological: 36.3
• Monoisotopic Mass: 208.1383080
• Synonyms: 1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 628-091-8, 847818-74-0, 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester, 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, 1H-PYRAZOLE, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, MFCD05861380, 1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole, 1-METHYLPYRAZOLE-5-BORONIC ACID PINACOL ESTER, 1H-PYRAZOLE,1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-, 4,4,5,5-tetramethyl-2-(1-methylpyrazol-5-yl)-1,3,2-dioxaborolane, 1-METHYL-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-1H-PYRAZOL, 1-methyl-pyrazole-5-boronic acid pinacol ester, SCHEMBL332693, CHEMBL3236900, 1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, DTXSID80406728, HLXOVAMYQUFLPE-UHFFFAOYSA-N, ALBB-012241, BCP14540, CS-M2919, SBB013484, TD8153, AKOS000302127, HN-0017, PB29351, NCGC00662690-01, AC-25463, SY017147, M2681, ST50570735, EN300-152536, 1-methyl-1-H-pyrazole-5-boronic acid pinacol ester, 1-Methyl-1H-pyrazole-5-boronic acid pinacol ester, 97%, F0001-3332, Z1336745146, (1-METHYL-1H-PYRAZOL-5-YL)BORONIC ACID PINACOL ESTER, 1-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROL, 1-methyl-5-(4,4,5,5-tetrarnethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen 1-methyl-1H-pyrazol-5-ylboronate, 2-(1-METHYL-1H-PYRAZOL-5-YL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE, 2-METHYL-3-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2H-PYRAZOLE

This boronic ester is primarily employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura) to construct biaryl and heteroaryl scaffolds prevalent in pharmaceuticals and agrochemicals. It serves as a key intermediate in the synthesis of kinase inhibitors and other bioactive molecules. The pinacol-protected boronate group enhances stability while maintaining reactivity under mild conditions. Suitable for automated synthesis platforms due to its consistent performance.

Safety and Hazards

GHS Hazard Statements

• H302 (97.7%): Harmful if swallowed [Warning Acute toxicity, oral]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (97.7%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.7%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.