Description

2-Chloro-4-fluoro-5-nitrophenol (CAS No. 84478-75-1) is a high-purity nitro-substituted phenol derivative designed for advanced research and industrial applications. With the molecular formula C₆H₃ClFNO₃, this compound serves as a versatile intermediate in organic synthesis, particularly in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring chloro, fluoro, and nitro functional groups, enables selective reactivity for coupling reactions, nucleophilic substitutions, and heterocycle formation. Available in >98% purity (HPLC/GC), this product is rigorously tested for consistency and stability, ensuring reliable performance in sensitive applications. Packaged under inert conditions to prevent degradation, it is ideal for use in catalysis, ligand design, and fine chemical synthesis.

Properties

• CAS Number: 84478-75-1
• Complexity: 186
• IUPAC Name: 2-chloro-4-fluoro-5-nitro-phenol
• InChI: InChI=1S/C6H3ClFNO3/c7-3-1-4(8)5(9(11)12)2-6(3)10/h1-2,10H
• InChI Key: NAWVMCKMQMJQMF-UHFFFAOYSA-N
• Exact Mass: 190.9785488
• Molecular Formula: C6H3ClFNO3
• Molecular Weight: 191.54
• SMILES: C1=C(C(=CC(=C1O)Cl)F)[N+](=O)[O-]
• Topological: 66.1
• Monoisotopic Mass: 190.9785488
• Synonyms: 2-Chloro-4-fluoro-5-nitrophenol, 84478-75-1, Phenol, 2-chloro-4-fluoro-5-nitro-, DTXSID50233462, DTXCID50155953, 671-719-0, 2-chloro-4-fluoro-5-nitro-phenol, MFCD02670258, 2-Chloro-4-fluoro-5-nitrobenzenol, SCHEMBL811001, SCHEMBL13066127, NAWVMCKMQMJQMF-UHFFFAOYSA-N, AC-239, CL4108, SBB055201, AKOS005069486, CS-W015839, 2-fluoro-4-chloro-5-hydroxynitrobenzene, 11L-319S, SY006283, DB-020812, 4-chloro-2-fluoro-5-hydroxy-1-nitrobenzene, C2616, ST50411915, EN300-371955

2-Chloro-4-fluoro-5-nitrophenol is widely used as a building block in pharmaceutical synthesis, particularly for antimicrobial and herbicide intermediates. Its reactive nitro and halogen groups facilitate cross-coupling reactions in Pd-catalyzed transformations. Researchers also employ it in dye synthesis and as a precursor for advanced polymer modifiers. Handle with standard safety precautions for nitroaromatics.

Safety and Hazards

GHS Hazard Statements

• H302+H312+H332 (90.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
• H302 (96.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H312 (93.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H332 (96.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]
• H335 (93.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Acute Tox. 4 (96.8%)
• Acute Tox. 4 (93.5%)
• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• Acute Tox. 4 (96.8%)
• STOT SE 3 (93.5%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.