Description

4-Methoxybenzyl Chloride (CAS No. 824-94-2) is a versatile organic compound with the molecular formula C₈H₉ClO, widely used in synthetic organic chemistry and pharmaceutical research. This reagent serves as a key intermediate for the introduction of the 4-methoxybenzyl (PMB) protecting group, which is essential in peptide synthesis, carbohydrate chemistry, and the preparation of complex organic molecules. The product is stabilized with potassium carbonate to ensure optimal shelf life and performance.

Our high-purity 4-Methoxybenzyl Chloride (≥98%) is rigorously tested for consistency, ensuring reliable results in your laboratory applications. It is supplied in amber glass bottles to protect against light degradation and stored under controlled conditions to maintain its integrity. Ideal for researchers and industrial scientists requiring a dependable reagent for nucleophilic substitutions, alkylations, and protecting group strategies.

Properties

• CAS Number: 824-94-2
• Complexity: 87.3
• IUPAC Name: 1-(chloromethyl)-4-methoxy-benzene
• InChI: InChI=1S/C8H9ClO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6H2,1H3
• InChI Key: MOHYOXXOKFQHDC-UHFFFAOYSA-N
• Exact Mass: 156.0341926
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.61
• SMILES: COC1=CC=C(C=C1)CCl
• Topological: 9.2
• Monoisotopic Mass: 156.0341926
• Synonyms: 4-Methoxybenzyl chloride, 824-94-2, 1-(Chloromethyl)-4-methoxybenzene, p-Methoxybenzyl chloride, p-Anisyl chloride, Benzene, 1-(chloromethyl)-4-methoxy-, alpha-Chloro-4-methoxytoluene, p-(Chloromethyl)anisole, Anisole, p-(chloromethyl)-, 4-(Chloromethyl)anisole, 4-Methyloxybenzyl chloride, CCRIS 5108, .alpha.-Chloro-4-methoxytoluene, 4-(chloromethyl)-1-methoxybenzene, EINECS 212-540-6, NSC 172955, Q500ZS03TI, 4-(chloromethyl)phenyl methyl ether, NSC-172955, 1-(chloromethyl)-4-(methyloxy)benzene, DTXSID20231718, .ALPHA.-CHLORO-P-METHOXYTOLUENE, DTXCID50154209, Anisole, p-(chloromethyl)-(8CI), ALPHA-CHLORO-P-METHOXYTOLUENE, Benzene, 1-(chloromethyl)-4-methoxy-(9CI), inchi=1/c8h9clo/c1-10-8-4-2-7(6-9)3-5-8/h2-5h,6h2,1h, 4-methoxybenzylchloride, 4-Chloromethyl anisole, 1-Chloromethyl-4-methoxy-benzene, MFCD00000915, 1-(chloromethyl)-4-methoxy-benzene, para-methoxybenzyl chloride, 4-Methoxybenzyl Chloride (Stabilized), 1-CHLOROMETHYL-4-METHOXYBENZENE, UNII-Q500ZS03TI, PMBCl, p-methoxybenzylchlorid, p-methoxybenzylchoride, p-methoxybenzylchloride, PMB-Cl, 4-methoxybenzylchlorine, 4methoxybenzyl chloride, 4-Methyoxybenzylchloride, 4-methoxy benzylchloride, 4-methoxybenzyl-chloride, 4-Methoxy-benzylchloride, para-methoxybenzylchloride, paramethoxybenzyl chloride, 4-methoxylbenzyl chloride, 4-methyoxybenzyl chloride, p-methoxy benzyl chloride, 4-methoxy benzyl chloride, 4-methoxy-benzyl chloride, a-chloro-4-methoxytoluene, para-methoxy benzylchloride, 4-methoxyl benzyl chloride, Para methoxy benzylchloride, 4-(methoxy)benzyl chloride, para-Methoxy benzyl chloride, para-methoxyl benzyl chloride, SCHEMBL13096, 4-methoxyphenylmethyl chloride, SCHEMBL3958751, SCHEMBL6959984, (4-methoxyphenyl)methyl chloride, l-(chloromethyl)-4-methoxybenzene, 4-Methoxybenzylchloride, stabilized, BCP25855, STR01214, 1-(chloro methyl)-4-methoxybenzene, NSC172955, SBB040608, AKOS000262023, CS-W017991, FM04196, M0676, NS00038207, ST50214006, EN300-49219, F11275, 4-(Chloromethyl)anisole;a-Chloro-4-methoxytoluene, Q27287004, 4-(Chloromethyl)anisole; 1-Chloromethyl-4-methoxybenzene, F0001-2114, 4-Methoxybenzyl Chloride (stabilized with Potassium carbonate), 4-Methoxybenzyl chloride – stabilised with potassium carbonate, 4-METHOXYBENZYL CHLORIDE (CONTAINS POTASSIUM CARBONATE AS STABILIZER), 4-Methoxybenzyl chloride, contains potassium carbonate as stabilizer, 98%

4-Methoxybenzyl Chloride is primarily used as a protecting group reagent for alcohols and amines in organic synthesis. It is also employed in the synthesis of pharmaceuticals, agrochemicals, and fine chemicals. The compound is particularly valuable in peptide coupling reactions and as a precursor for chiral auxiliaries. Its stability and reactivity make it a preferred choice for multi-step synthetic routes.

Safety and Hazards

GHS Hazard Statements

• H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Precautionary Statements

• P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501

Hazard Classes and Categories

• Skin Corr. 1B (100%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.