Description

3,5-Dichloro-2-fluoropyridine (CAS No. 823-56-3) is a high-purity halogenated pyridine derivative widely utilized in pharmaceutical and agrochemical research. This compound, with the molecular formula C₅H₂Cl₂FN, serves as a versatile building block for synthesizing complex heterocyclic structures. Its unique reactivity, attributed to the electron-withdrawing effects of chlorine and fluorine substituents, makes it invaluable for nucleophilic aromatic substitution (S_NAr) reactions and cross-coupling methodologies. Available in >98% purity (GC), it is supplied in rigorously tested batches to ensure consistency for sensitive applications. Proper storage under inert atmosphere at 2-8°C is recommended to maintain stability.

Properties

• CAS Number: 823-56-3
• Complexity: 101
• IUPAC Name: 3,5-dichloro-2-fluoro-pyridine
• InChI: InChI=1S/C5H2Cl2FN/c6-3-1-4(7)5(8)9-2-3/h1-2H
• InChI Key: FHQWUIZMJXPGRG-UHFFFAOYSA-N
• Exact Mass: 164.9548326
• Molecular Formula: C5H2Cl2FN
• Molecular Weight: 165.98
• SMILES: C1=C(C=NC(=C1Cl)F)Cl
• Topological: 12.9
• Monoisotopic Mass: 164.9548326
• Synonyms: 3,5-Dichloro-2-fluoropyridine, 823-56-3, FHQWUIZMJXPGRG-UHFFFAOYSA-, DTXSID10382541, DTXCID40333566, 676-837-6, inchi=1/c5h2cl2fn/c6-3-1-4(7)5(8)9-2-3/h1-2h, 2-Fluoro-3,5-dichloropyridine, MFCD04039349, PYRIDINE, 3,5-DICHLORO-2-FLUORO-, 3,5-DICHLORO-6-FLUOROPYRIDINE, SCHEMBL232179, SCHEMBL7171869, FHQWUIZMJXPGRG-UHFFFAOYSA-N, SBB087952, AKOS005064126, AC-6254, CS-W016070, DS-0543, SB52443, SY046982, DB-023657, D3317, ST50408281, EN300-88331

Application

3,5-Dichloro-2-fluoropyridine is extensively employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for antiviral and antibacterial agents. Its structural motif is critical in developing herbicides and pesticides due to enhanced bioactivity from halogen substitution. Researchers also utilize it in material science for creating functionalized pyridine-based ligands in catalysis.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (94.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2A (100%)
• STOT SE 3 (94.4%)

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