Description

Bis(2-chloroethyl)amine hydrochloride (CAS No. 821-48-7) is a highly specialized chemical compound with the molecular formula C₄H₁₀Cl₃N. This white crystalline powder is a derivative of nitrogen mustard and is widely utilized in pharmaceutical research, particularly in the development of alkylating agents for chemotherapy. With a purity of ≥98%, this product is rigorously tested to meet the highest industry standards, ensuring consistency and reliability for critical laboratory applications. Its hygroscopic nature necessitates storage under inert conditions to maintain stability. Suitable for use in organic synthesis, medicinal chemistry, and biochemical studies, this compound is packaged in amber glass vials to protect against light degradation. Each batch is accompanied by comprehensive analytical documentation, including HPLC, NMR, and MS data, to support your research needs.

Properties

• CAS Number: 821-48-7
• Complexity: 28.9
• IUPAC Name: 2-chloro-N-(2-chloroethyl)ethanamine;hydrochloride
• InChI: InChI=1S/C4H9Cl2N.ClH/c5-1-3-7-4-2-6;/h7H,1-4H2;1H
• InChI Key: YMDZDFSUDFLGMX-UHFFFAOYSA-N
• Exact Mass: 176.987882
• Molecular Formula: C4H10Cl3N
• Molecular Weight: 178.48
• SMILES: C(CCl)NCCCl.Cl
• Topological: 12
• Monoisotopic Mass: 176.987882
• Physical Description: Off-white powder with an irritating odor;
• Synonyms: Bis(2-chloroethyl)amine hydrochloride, 821-48-7, Bis(2-chloroethyl)ammonium chloride, nor-Lost hydrochlorid, Nor-HN2 hydrochloride, di(2-chloroethyl)amine hydrochloride, DTXSID3052567, Di-2-chloroethylamine hydrochloride, Bi(2-chloroethyl)amine hydrochloride, NSC 10873, NSC-10873, 1,5-Dichloro-3-azapentane hydrochloride, LEO-72A, Bis(.beta.-chloroethyl)amine hydrochloride, DTXCID4031140, LY407360DG, Nor-lost hydrochlorid [German], Bis(beta-chloroethyl)amine hydrochloride, Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride (1:1), EINECS 212-479-5, Bis(beta-chloroethyl)-amine hydrochloride, AI3-32120, UNII-LY407360DG, Norlost hydrochlorid, NorHN2 hydrochloride, Di2chloroethylamine hydrochloride, Bis(2chloroethyl)ammonium chloride, 2,2’Dichlorodiethylamine hydrochloride, Bis(betachloroethyl)amine hydrochloride, N,NBis(2chloroethyl)amine hydrochloride, Diethylamine, 2,2’dichloro, hydrochloride, beta,beta’Dichlorodiethylamine hydrochloride, 2ChloroN(2chloroethyl)ethanamine hydrochloride, Ethanamine, 2chloroN(2chloroethyl), hydrochloride, 212-479-5, un2923, 2,2′-Dichlorodiethylamine hydrochloride, 2-Chloro-N-(2-chloroethyl)ethanamine hydrochloride, MFCD00012515, Nornitrogen mustard hydrochloride, N,N-Bis(2-chloroethyl)amine hydrochloride, Ethanamine, 2-chloro-N-(2-chloroethyl)-, hydrochloride, LEO 72a, 2-chloro-N-(2-chloroethyl)ethanamine;hydrochloride, 1011513-93-1, Bis(2-chloroethyl)amine (hydrochloride), NC 26, SK 555, TL 161, .beta.,.beta.’-Dichlorodiethylamine hydrochloride, DIETHYLAMINE, 2,2′-DICHLORO-, HYDROCHLORIDE, Bis(2-chloroethyl)amine HCl, C4H10Cl3N, Di-(2-Chloroethyl)amine hydrochloride, bis-(2-chloroethyl)amine hydrochloride, WLN: G2M2G &GH, 2-Chloro-N-(2-chloroethyl)ethylamine hydrochloride, SCHEMBL246133, bischloroethylamine hydrochloride, bis-chloroethylamine hydrochloride, Nor-nitrogen mustard hydrochloride, bis(chloroethyl)amine hydrochloride, HY-Y0881, NSC10873, STR04145, Bis(2-chloroethyl)aminehydrochloride, Tox21_303731, bis(2-chloroethyl) ammonium chloride, bis-(2-chloroethyl)ammonium chloride, bis-(2-choroethyl)amine hydrochloride, AKOS005258967, bis (2-chloroethyl)amine hydrochloride, bis(2- chloroethyl)amine hydrochloride, bis(2-chloroethyl)-amine hydrochloride, bis(2-chloroethyl)amine, hydrochloride, Bis(2-chloroethyl) amine hydrochloride, CS-W020124, bis (2-chloroethyl) amine hydrochloride, Bis(2-Chloroethyl)Amine Hydro Chloride, bis(2-chloroethyl)amine hydrogenchloride, bis-(2-chloro-ethyl)amine hydrochloride, Bis-(2-chloroethyl) amine hydrochloride, bis-(2-chloroethyl)-amine hydrochloride, bis(2-chloroethyl)amine monohydrochloride, Diethylamine,2′-dichloro-, hydrochloride, NCGC00357040-01, ss,ss’-Dichlorodiethylamine hydrochloride, 1,5-Dichloro-3-azapentane, hydrochloride, AC-22676, bis(2-chloroethyl)amine hydrochloric acid, bis-(2-chloro-ethyl)-amine hydrochloride, CAS-821-48-7, PD065600, bis(2-chloroethyl)amine hydrochloride salt, bis-(2-chloroethyl)amine hydrochloride salt, B1210, Bis(2-chloroethyl)amine hydrochloride, 98%, NS00041954, EN300-18218, 2-Chloro-N-(2-chloroethyl)ethanaminium chloride, 2-Chloro-n-(2-chloroethyl)-ethanaminhydrochloride, 2-chloro-N-(2-chloroethyl)-ethanamine hydrochloride, Z57388616, F0001-2106

Bis(2-chloroethyl)amine hydrochloride is primarily employed as an intermediate in the synthesis of nitrogen mustard-based chemotherapeutic agents. It serves as a key building block in medicinal chemistry for developing alkylating agents that target DNA replication in cancer cells. Researchers also utilize this compound in biochemical studies to investigate mechanisms of alkylation and cytotoxicity. Its applications extend to the preparation of analogs for structure-activity relationship (SAR) studies in drug discovery.

Safety and Hazards

GHS Hazard Statements

• H290 (16.2%): May be corrosive to metals [Warning Corrosive to Metals]
• H302 (33.8%): Harmful if swallowed [Warning Acute toxicity, oral]
• H314 (36.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
• H315 (63.2%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (61.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H331 (27.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]
• H335 (61.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
• H340 (20.6%): May cause genetic defects [Danger Germ cell mutagenicity]
• H341 (14.7%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
• H350 (19.1%): May cause cancer [Danger Carcinogenicity]

Precautionary Statements

• P203, P234, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P363, P390, P403+P233, P405, P406, and P501

Hazard Classes and Categories

• Met. Corr. 1 (16.2%)
• Acute Tox. 4 (33.8%)
• Skin Corr. 1B (36.8%)
• Skin Irrit. 2 (63.2%)
• Eye Irrit. 2 (61.8%)
• Acute Tox. 3 (27.9%)
• STOT SE 3 (61.8%)
• Muta. 1A (20.6%)
• Muta. 2 (14.7%)
• Carc. 1A (19.1%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.