Description

2,4-Difluorophenylacetic acid (CAS No. 81228-09-3) is a high-purity fluorinated organic compound with the molecular formula C₈H₆F₂O₂ and IUPAC name 2-(2,4-difluorophenyl)acetic acid. This white to off-white crystalline powder is a versatile building block in pharmaceutical, agrochemical, and materials science research. With a molecular weight of 172.13 g/mol, it offers excellent reactivity for derivatization and coupling reactions. Our product is rigorously tested to ensure ≥98% purity (HPLC) and is supplied in sealed containers under inert atmosphere to guarantee stability. Ideal for Suzuki couplings, peptide synthesis, and as a precursor for bioactive molecules, this compound is a must-have for medicinal chemists exploring fluorinated scaffolds. Available in quantities from 1g to 1kg with customizable packaging options.

Properties

• CAS Number: 81228-09-3
• Complexity: 172
• IUPAC Name: 2-(2,4-difluorophenyl)acetic acid
• InChI: InChI=1S/C8H6F2O2/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2,(H,11,12)
• InChI Key: QPKZIGHNRLZBCL-UHFFFAOYSA-N
• Exact Mass: 172.03358575
• Molecular Formula: C8H6F2O2
• Molecular Weight: 172.13
• SMILES: C1=CC(=C(C=C1F)F)CC(=O)O
• Topological: 37.3
• Monoisotopic Mass: 172.03358575
• Synonyms: 2,4-Difluorophenylacetic acid, 81228-09-3, EINECS 279-709-4, DTXSID90230975, DTXCID20153466, 279-709-4, 2-(2,4-difluorophenyl)acetic acid, 2,4-Ddifluorophenylacetic acid, Benzeneacetic acid, 2,4-difluoro-, 2,4-DIFLUOROBENZENEACETIC ACID, MFCD00009999, (2,4-difluorophenyl)acetic acid, 2,4-Difluorophenylaceticacid, 2,4-Difluorophenylacetic Acid; 2-(2,4-Difluorophenyl)acetic Acid, T6F7M4HV6T, SCHEMBL503325, QPKZIGHNRLZBCL-UHFFFAOYSA-, (2,4-difluoro-phenyl)acetic acid, SBB037936, 2,4-Difluorophenylacetic acid, 97%, AKOS005218000, AC-7443, CS-W020581, PS-8679, ST085769, SY017050, DB-030791, D4321, NS00060554, EN300-100639, F0001-2095, Z362118706, InChI=1/C8H6F2O2/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2,(H,11,12)

Application

2,4-Difluorophenylacetic acid serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly NSAIDs and antifungal agents. Its difluorophenyl moiety enhances metabolic stability and bioavailability in drug candidates. The compound is widely used in peptide modification to introduce hydrophobic, fluorine-containing side chains. Researchers also employ it as a precursor for liquid crystal materials and specialty polymers requiring fluorinated aromatic components.

Safety and Hazards

GHS Hazard Statements

• H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
• H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
• H335 (97.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

• P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

• Skin Irrit. 2 (100%)
• Eye Irrit. 2 (100%)
• STOT SE 3 (97.9%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.