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Atomfair 4-(tert-Butyl)-2-chloropyridine C9H12ClN CAS 81167-60-4

4-(tert-Butyl)-2-chloropyridine (CAS No. 81167-60-4) is a high-purity chlorinated pyridine derivative with the molecular formula C9H12ClN. This compound is characterized by the presence of a tert-butyl group at the 4-position and a chloro substituent at the 2-position of the pyridine ring, offering unique steric and electronic properties for advanced synthetic applications. Ideal for researchers and scientists, this reagent is rigorously tested for quality, ensuring optimal performance in organometallic coupling reactions, pharmaceutical intermediates, and agrochemical synthesis. Supplied in sealed containers under inert conditions to guarantee stability and longevity. Purity is verified via GC/MS, NMR, and HPLC analysis to meet stringent laboratory standards.

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Description

4-(tert-Butyl)-2-chloropyridine (CAS No. 81167-60-4) is a high-purity chlorinated pyridine derivative with the molecular formula C9H12ClN. This compound is characterized by the presence of a tert-butyl group at the 4-position and a chloro substituent at the 2-position of the pyridine ring, offering unique steric and electronic properties for advanced synthetic applications. Ideal for researchers and scientists, this reagent is rigorously tested for quality, ensuring optimal performance in organometallic coupling reactions, pharmaceutical intermediates, and agrochemical synthesis. Supplied in sealed containers under inert conditions to guarantee stability and longevity. Purity is verified via GC/MS, NMR, and HPLC analysis to meet stringent laboratory standards.

Properties

  • CAS Number: 81167-60-4
  • Complexity: 128
  • IUPAC Name: 4-tert-butyl-2-chloro-pyridine
  • InChI: InChI=1S/C9H12ClN/c1-9(2,3)7-4-5-11-8(10)6-7/h4-6H,1-3H3
  • InChI Key: UGGNULHQVUWRGQ-UHFFFAOYSA-N
  • Exact Mass: 169.0658271
  • Molecular Formula: C9H12ClN
  • Molecular Weight: 169.65
  • SMILES: CC(C)(C)C1=CC(=NC=C1)Cl
  • Topological: 12.9
  • Monoisotopic Mass: 169.0658271
  • Synonyms: 4-(tert-butyl)-2-chloropyridine, 834-439-1, 81167-60-4, 4-TERT-BUTYL-2-CHLOROPYRIDINE, 4-tert-Butyl-2-chloro-pyridine, 4-T-BUTYL-2-CHLORO-PYRIDINE, MFCD12131129, Pyridine, 2-chloro-4-(1,1-dimethylethyl)-, chloro(4-t-butylpyridine), 2-chloro-4-terbutylpyridine, 2-Chloro-4-t-butylpyridine, SCHEMBL803495, 2-Chloro-4-tert-butylpyridine, DTXSID00721046, GDA16760, SBB088347, AKOS023570322, AB65343, CS-W022028, DS-8376, SY105781, DB-367973, B5466, EN300-86206

Application

4-(tert-Butyl)-2-chloropyridine serves as a versatile building block in medicinal chemistry for the synthesis of bioactive molecules and drug candidates. Its sterically hindered structure makes it valuable in catalytic cross-coupling reactions, such as Suzuki-Miyaura or Negishi couplings. The compound is also employed in material science for designing ligands in coordination chemistry and as a precursor for functionalized pyridine derivatives.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • STOT SE 3 (50%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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