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Atomfair (4-Aminophenyl)boronic acid hydrochloride 4-APBA·HCl C6H9BClNO2 CAS 80460-73-7

(4-Aminophenyl)boronic acid hydrochloride (CAS: 80460-73-7) is a high-purity boronic acid derivative with the molecular formula C6H9BClNO2. This compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its versatile reactivity as a boronic acid reagent. It serves as a critical intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds for advanced drug discovery and polymer development. The hydrochloride salt form enhances stability and solubility, making it suitable for aqueous reaction conditions. Available in various purities (e.g., ≥95%), this product is rigorously tested by HPLC, NMR, and mass spectrometry to ensure consistency for sensitive applications.…

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Description

(4-Aminophenyl)boronic acid hydrochloride (CAS: 80460-73-7) is a high-purity boronic acid derivative with the molecular formula C6H9BClNO2. This compound is widely utilized in organic synthesis, pharmaceutical research, and material science due to its versatile reactivity as a boronic acid reagent. It serves as a critical intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds for advanced drug discovery and polymer development. The hydrochloride salt form enhances stability and solubility, making it suitable for aqueous reaction conditions. Available in various purities (e.g., ≥95%), this product is rigorously tested by HPLC, NMR, and mass spectrometry to ensure consistency for sensitive applications. Store under inert conditions (2-8°C) to maintain optimal performance.

Properties

  • CAS Number: 80460-73-7
  • Complexity: 102
  • IUPAC Name: (4-aminophenyl)boronic acid;hydrochloride
  • InChI: InChI=1S/C6H8BNO2.ClH/c8-6-3-1-5(2-4-6)7(9)10;/h1-4,9-10H,8H2;1H
  • InChI Key: QBYGJJSFMOVYOA-UHFFFAOYSA-N
  • Exact Mass: 173.0414864
  • Molecular Formula: C6H9BClNO2
  • Molecular Weight: 173.41
  • SMILES: B(C1=CC=C(C=C1)N)(O)O.Cl
  • Topological: 66.5
  • Monoisotopic Mass: 173.0414864
  • Synonyms: (4-aminophenyl)boronic Acid Hydrochloride, 623-030-1, 80460-73-7, 4-Aminophenylboronic acid hydrochloride, 4-Aminobenzeneboronic acid hydrochloride, 4-Aminophenylboronic acid, HCl, 4-AMINOPHENYLBORONIC ACID HCL, MFCD03001333, (4-aminophenyl)boronic acid;hydrochloride, SC-52150, Boronic acid, (4-aminophenyl)-, hydrochloride, SCHEMBL40937, 4-borono-benzenaminium chloride, DTXSID80370394, RB3072, SBB070184, (4-aminophenyl)boronic acid HCl salt, AKOS005146544, (4-aminophenyl)boronicAcidHydrochloride, AC-6979, CS-W000970, FA33740, GS-6621, 4-aminophenyl-boronic acid hydrochloride, SY017592, DB-024853, 4-Aminophenylboronic acid hydrochloride, 95%, B-(4-Aminophenyl)-boronic Acid Hydrochloride;, EN300-316295, Z1741970842, 4-Aminophenylboronic acid hydrochloride(contains varying amounts of Anhydride)

This compound is primarily used as a key reagent in Suzuki-Miyaura cross-coupling for biaryl synthesis in drug development. It also functions as a sensor precursor for glucose detection systems due to its affinity for diols. Researchers employ it in covalent organic framework (COF) design and as a ligand in catalysis. Its amine group allows further functionalization for targeted molecular probes.

Safety and Hazards

GHS Hazard Statements

  • H302 (87%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H315 (15.2%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (15.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (15.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (87%)
  • Skin Irrit. 2 (15.2%)
  • Eye Irrit. 2A (15.2%)
  • STOT SE 3 (15.2%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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