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Atomfair 5-(trifluoromethyl)pyridine-2-carboxylic Acid C7H4F3NO2 CAS 80194-69-0

5-(Trifluoromethyl)pyridine-2-carboxylic Acid (CAS No. 80194-69-0) is a high-purity fluorinated pyridine derivative with the molecular formula C7H4F3NO2. This compound is a versatile building block in pharmaceutical, agrochemical, and materials science research, featuring a reactive carboxylic acid group and a stable trifluoromethyl (-CF3) moiety. Its unique structure enables applications in drug design, catalysis, and specialty polymers. Available in ≥98% purity (HPLC), it is supplied as a white to off-white crystalline powder with strict quality control (GC/MS, NMR) to ensure batch consistency. Store in a cool, dry place under inert conditions to maintain stability. Suitable for in vitro and in vivo studies.

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Description

5-(Trifluoromethyl)pyridine-2-carboxylic Acid (CAS No. 80194-69-0) is a high-purity fluorinated pyridine derivative with the molecular formula C7H4F3NO2. This compound is a versatile building block in pharmaceutical, agrochemical, and materials science research, featuring a reactive carboxylic acid group and a stable trifluoromethyl (-CF3) moiety. Its unique structure enables applications in drug design, catalysis, and specialty polymers. Available in ≥98% purity (HPLC), it is supplied as a white to off-white crystalline powder with strict quality control (GC/MS, NMR) to ensure batch consistency. Store in a cool, dry place under inert conditions to maintain stability. Suitable for in vitro and in vivo studies.

Properties

  • CAS Number: 80194-69-0
  • Complexity: 204
  • IUPAC Name: 5-(trifluoromethyl)pyridine-2-carboxylic acid
  • InChI: InChI=1S/C7H4F3NO2/c8-7(9,10)4-1-2-5(6(12)13)11-3-4/h1-3H,(H,12,13)
  • InChI Key: NJHGVAYLDHROPT-UHFFFAOYSA-N
  • Exact Mass: 191.01941286
  • Molecular Formula: C7H4F3NO2
  • Molecular Weight: 191.11
  • SMILES: C1=CC(=NC=C1C(F)(F)F)C(=O)O
  • Topological: 50.2
  • Monoisotopic Mass: 191.01941286
  • Synonyms: 80194-69-0, 5-(trifluoromethyl)pyridine-2-carboxylic Acid, DTXSID40448028, DTXCID10398849, 635-973-6, 5-(trifluoromethyl)picolinic acid, 5-Trifluoromethyl-2-pyridinecarboxylic acid, 5-(Trifluoromethyl)-2-pyridinecarboxylic acid, MFCD04113632, 5-trifluoromethyl-pyridine-2-carboxylic acid, 2-PYRIDINECARBOXYLIC ACID, 5-(TRIFLUOROMETHYL)-, 5-(trifluoromethyl)-pyridine-2-carboxylic acid, 5-Trifluoromethylpicolinic Acid; 5-(Trifluoromethyl)-2-pyridinecarboxylic Acid, SCHEMBL211804, BCP20008, AR2108, BBL100541, SBB053043, STL554335, AKOS005072643, AB17699, CS-W008670, FC-0609, NCGC00331098-01, AC-24947, SY015455, 5-trifluoromethylpyridine-2-carboxylic acid, DB-011829, ST50949607, T2975, EN300-27612, AB01325306-02, 5-(Trifluoromethyl)pyridine-2-carboxylic acid, 95%, Z235344883

Application

5-(Trifluoromethyl)pyridine-2-carboxylic Acid is widely used as a key intermediate in the synthesis of bioactive molecules, particularly in the development of pharmaceuticals targeting CNS disorders and inflammation. Its trifluoromethyl group enhances metabolic stability, making it valuable for medicinal chemistry optimization. The compound also serves as a ligand in transition-metal catalysis for cross-coupling reactions. Researchers utilize it to modify peptides and polymers for improved physicochemical properties.

Safety and Hazards

GHS Hazard Statements

  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H335 (98.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2 (100%)
  • STOT SE 3 (98.6%)

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Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

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